Chapter category: Tissue Engineering

Repair of Osteochondral Lesions

This chapter appears in the following book:

Engineered Bone

Edited by: Hervé Petite and Rodolfo Quarto
ISBN: 1-58706-157-0
» Get more information about this book at landesbioscience.com «

Chapter authors:
Ivan Martin, Dirk Schaefer and Beatrice Dozin

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Trauma and disease of joints frequently involve structural damage to the articular cartilage surface and the underlying subchondral bone. These pathologies result in severe pain and disability for millions of people world-wide and represent a major challenge for the orthopaedic community. Albeit a series of therapeutic approaches has been developed to treat osteochondral defects, none of them has proved yet to ensure long-lasting regeneration. The difficulties encountered mostly rely on the intrinsic biological, biochemical and biomechanical properties of the articular cartilage. An accurate knowledge of these properties is mandatory to improve current therapies and/or establish innovative procedures. This chapter will (i) describe some of the structural and functional properties of articular cartilage; (ii) critically present the current procedures to repair cartilage; (iii) introduce a variety of novel strategies currently under investigation for cartilage repair and (iv) highlight some of the main challenges to be addressed in order to improve the clinical treatment of osteochondral lesions.

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Chapter category: Tissue Engineering

Repair of Osteochondral Lesions

Additional chapters from this book:

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