Chapter category: Protein
CD137 Pathway in Innate and Adaptive Immunity
TNF Superfamily
Edited by: Sanjay KhareISBN: 978-1-58706-306-0
» Get more information about this book at landesbioscience.com «
Chapter authors:
Ryan A. Wilcox and Lieping Chen
CD137 is a member of the TNF receptor superfamily which may be induced on a variety of cells, including activated T lymphocytes, natural killer cells and dendritic cells. Studies performed both in vitro and in vivo have suggested that CD137 activation pathway is capable of regulating cellular and molecular components of both innate and adaptive immunity. As we will discuss, interaction between CD137 receptor and its ligand may be a critical link between innate and adaptive immunity. Not surprisingly then, this receptor/ligand pair represents an attractive target for the immunotherapy. While there is ample evidence indicating that CD137 signaling promotes the regression of established tumors in mouse models, recent studies also demonstrate the role of CD137 in the inhibition of systemic autoimmune diseases in some animal models. Manipulation of this pathway may represent a promising approach for treatment of cancer and other immunological diseases.
Ryan A. Wilcox
Department of Immunology, Mayo Clinic
Lieping Chen
Department of Dermatology/Oncology, Johns Hopkins School of Medicine
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CD137 Pathway in Innate and Adaptive Immunity
Ryan A. Wilcox and Lieping Chen
CD137 is a member of the TNF receptor superfamily which may be induced on a variety of cells, including activated T lymphocytes, natural killer cells and dendritic cells. Studies performed bot...
