Chapter category: Extracellular Matrix
Pathological Significance of Renal Expression of Proinflammatory Molecules
Fibrogenesis: Cellular and Molecular Basis
Edited by: Mohammed Shawkat RazzaqueISBN: 0-306-47861-7
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Chapter authors:
Takashi Wada, Mohammed S. Razzaque, Kouji Matsushima, Takashi Taguchi and Hitoshi Yokoyama
Recent studies of cytokines, chemokines, adhesion molecules and growth factors have enhanced our understanding of molecular mechanisms of leukocyte trafficking and their activation in the inflammatory phase of various renal diseases. Interactions between infiltrated inflammatory cells and resident renal cells are actively involved in the pathogenesis of phase-specific renal disorders. Furthermore, a number of proinflammatory and fibrogenic cytokines, chemokines and growth factors exert their biological activities through their receptors expressed on resident renal cells, to induce inflammatory responses that eventually lead to the development of fibrosis in various renal diseases. Thus, measuring the levels of certain proinflammatory molecules might provide useful information about the inflammatory state of the diseased kidney and could have clinical importance and significance. The selective intervention of some of these molecules might have the therapeutic potential to modulate renal inflammatory responses, and thereby could alter disease progression. Despite the apparent redundancy, accumulating evidence supports this possibility. In this chapter, we will briefly summarize the specific roles of certain proinflammatory molecules in the pathogenesis of various human and experimental renal diseases.
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