Chapter category: Extracellular Matrix
Molecular Developments in the Treatment of Renal Fibrosis
Fibrogenesis: Cellular and Molecular Basis
Edited by: Mohammed Shawkat RazzaqueISBN: 0-306-47861-7
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Chapter authors:
Gavin J. Becker and Tim D. Hewitson
Progressive renal disease is associated with the development of fibrosing lesions not only in the glomerulus, but also in the interstitial and vascular compartments of the kidney, in a process that involves the mesenchymally derived, phenotypically similar, mesangial cell, myofibroblast and vascular smooth muscle cell. The similarities in the pathogenesis of all three processes means that the search for rational treatment strategies for any one may be of universal benefit to the others. Potential therapeutic strategies target fibrosis both indirectly and directly. Indirect therapies alter the environment the kidney operates in such as by controlling blood pressure, hyperlipidemia and hyperglycaemia. As our understanding of the mechanisms of fibrosis increase, we are developing more direct treatment strategies that target the vasoactive mediators, growth factors and cell signaling pathways that regulate renal fibrogenesis. Finally attempts to increase collagen degradation and maintain blood supply are likely to reduce the damage resulting from aberrant collagen synthesis.
Additional chapters from this book:
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Currently, hepatic fibrogenesis is viewed as a dynamic process strictly related to the extent and duration of liver injury. Activated hepatic stellate cells (HSCs) are identi fied as the major sourc...
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Molecular Developments in the Treatment of Renal Fibrosis
Gavin J. Becker and Tim D. Hewitson
Progressive renal disease is associated with the development of fibrosing lesions not only in the glomerulus, but also in the interstitial and vascular compartments of the kidney, in a process that ...
Low-Density Lipoprotein and Glomerulosclerosis
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Hypercholesterolemia is a common feature of nephrosis or uremia. Dietary hypercholesterolemia aggravates the renal injury in experimental focal segmental glomerulosclerosis (FSGS). Hypercholesterole...
Involvement of NF-kB in Renal Inflammation and Sclerosis
Laurent Baud, Bruno Fouqueray, Agnes Bellocq, Jean-Philippe Haymannn and Julie Peltier
Nuclear factor-kB (NF-kB) comprises a family of transcription factors. They are thought to have a central role in the expression of genes involved in cell mobilization, cell proliferation and cell d...
Oxidative Stress, Lipoproteins and Angiotensin II— The Unholy Triade in the Pathogenesis of Renal Fibrosis
Jan Galle, Thomas Quaschning and Stefan Seibold
Renal fibrosis usually indicates irreversible tissue damage, irrespective of the initial cause. Thus, it is most relevant to understand mechanisms leading to renal fibrosis. Oxidative stress has eme...
Pathological Significance of Renal Expression of Proinflammatory Molecules
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Recent studies of cytokines, chemokines, adhesion molecules and growth factors have enhanced our understanding of molecular mechanisms of leukocyte trafficking and their activation in the inflammato...
Tissue Scarring Lessons from Wound Healing
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Tissue scarring due to abnormal matrix remodeling is an important cause of organ fail ure, which is a leading cause of morbidity and mortality. Current studies have focused on determination of the m...
Can Manipulation of Apoptotic Cell Death Benefit Tissue Scarring?
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Cell death by apoptosis is an active process of cell removal that is initiated and regulated by activation of specific enzymes and signaling molecules. In contrast to necrotic cell death, apoptotic ...
Pulmonary Firbogenesis: The Role of Apoptosis and its Clinical Potentials
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Pulmonary fibrosis is a common response to various insults or injuries to the lung. Al though there are various initiating factors or causes, the terminal stages are characterized by proliferatio...
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Hepatic stellate cells play essential roles in the pathogenesis of liver fibrosis. Transformation of stellate cells from the vitamin A-storing pheno type to the “myofibroblastic” one closely corr...
