Chapter category: Extracellular Matrix
Cardiac Fibrosis and Aging
Fibrogenesis: Cellular and Molecular Basis
Edited by: Mohammed Shawkat RazzaqueISBN: 0-306-47861-7
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Chapter authors:
Serge Masson, Roberto Latini, Monica Salio and Fabio Fiordaliso
Excessive deposition of extracellular matrix proteins during aging leads to a progressive reduction of myocardial and arterial compliances. The increased cardiovascular stiffness may in turn determine a reduced capacity of the aged heart to respond to stressful situations. Our knowledge on the biology of extracellular matrix during aging derives mainly from observations made in animal models. The age-dependent accumulation of collagen in the heart is not related to an increased synthesis, but rather to a reduction of its degradation by specific matrix metalloproteinases and to an increased cross-linking of mature collagen that renders it more resistant to degradation. Specific pharmacological treatments are currently in use to limit or even reverse the progressive stiffening of the arteries and myocardium.
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