Chapter category: Cancer Metastasis
Maspin and Pericellular Plasminogen Activation in Cell-Matrix Interaction
Maspin
Edited by: Mary J.C. HendrixISBN: 1-58706-097-3
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Chapter authors:
Shijie Sheng, Hector Biliran Jr. and Richard McGowen
Maspin may offer a unique opportunity to block tumor invasion and metastasis. Maspin expression correlates with normality, and pre-malignant and/or less invasive lesions in breast, prostate and oral squamous cells.15 Therefore, maspin may be a useful molecular marker for the diagnosis and/or prognosis of cancer. Furthermore, accumulated evidence supports a tumor suppressive role of maspin, at the level of invasion and metastasis. For example, orthotopic explants of mammary carcinoma cells transfected with maspin coding cDNA are inhibited in tumor growth and metastasis in nude mouse experiments.1 These maspin transfectants are significantly inhibited in in vitro invasion and motility assays.1,6 Consistently, three forms of recombinant human maspin proteins produced in the bacterium E. coli, yeast S. cerevisiae, and baculo-virus infected insect cells Sf9, respectively, exhibit potent inhibitory effects on the invasion and motility of an array of human mammary and prostatic carcinoma cell lines in vitro.7,8 Treatment of human mammary carcinoma cells with maspin leads to a partial restoration of benign epithelial morphology and an increased cell adhesion to fibronectin.9 Recently, Zhang et al showed that recombinant mouse maspin inhibits the metastasis of human prostate tumor xenografts in nude mice.10 These data suggest a potential clinical application of maspin in cancer intervention.
Additional chapters from this book:
Maspin, a Potential Prognostic Marker for Human Cancers
Mickey C-T. Hu, Weiya Xia and Mien-Chie Hung
Maspin (mammary serine protease inhibitor) is a 42 kDa protein that shares significant sequence homology with several members of the serpin (serine prot...
The Role of Maspin in Human Placental Development
Anuja Dokras, Lynn M.G. Gardner, Dawn A. Kirschmann, Elisabeth A. Seftor and Mary J.C. Hendrix
The human placenta is hemochorial and displays highly regulated invasive activity and exponential growth potential. The stem cell cytotrophoblasts undergo differentiation along two...
The Role of Maspin in Tumor Progression and Normal Development
Ming Zhang
Serine protease inhibitors (serpins) are comprised of a large family of molecules that play a variety of physiological roles in vivo.1-3 Not all molecules that in...
Maspin Suppresses Breast Cancer Cell Invasiveness by Modulating Integrin Expression and Function
Richard E.B. Seftor, Valerie A. Odero, Elisabeth A. Seftor and Mary J.C. Hendrix
Although the novel tumor suppressor gene maspin (mammary serine protease inhibitor) was originally isolated from normal mammary epithelium by subtractive hybridization and d...
Genetic and Epigenetic Regulation of Maspin Gene Expression in Normal and Tumor Tissue
Frederick E. Domann and Bernard W. Futscher
Maspin, a tumor suppressor gene, encodes a protein that has been shown to restrict breast cancer cell motility, invasion, and metastasis. Expression of the maspin gene is commonly ...
Maspin and Pericellular Plasminogen Activation in Cell-Matrix Interaction
Shijie Sheng, Hector Biliran Jr. and Richard McGowen
Maspin may offer a unique opportunity to block tumor invasion and metastasis. Maspin expression correlates with normality, and pre-malignant and/or less invasive lesions in breast,...
Maspin and Myoepithelial Cells
Sanford H. Barsky, Paul Kedeshian and Mary L. Alpaugh
Host cellular paracrine regulation of tumor progression is an important determinant of tumor growth, invasion and metastasis but one cell which has largely been ignored in this reg...
Maspin: Functional Insights from a Structural Perspective
Philip A. Pemberton
Since the seminal paper by Zou et al1 identifying the existence of the novel tumor suppressor maspin (mammary serpin), research efforts have largely focused on the mecha...
Maspin in the Sager Laboratory
Ming Zhang, Shijie Sheng and Arthur B. Pardee
Discovery of a disease-related gene marks only the beginning to a series of difficult investigations. In order to establish the functional role of the newly discovered gene, one...
Ruth Sager, Geneticist
Arthur B. Pardee
Ruth Sager named her favorite gene Maspin, mammary serpin protease inhibitor. Expression of this gene is lost in advanced breast cancers and inhibits tumor invasion and metastas...
