Chapter category: Heart

Natural History of the Human Coronary Atherosclerotic Plaque and Related Forms of Myocardial Injuries

This chapter appears in the following book:

The Etiopathogenesis of Coronary Heart Disease:
A Heretical Theory Based on Morphology
Second Edition

Edited by: Giorgio Baroldi and Malcolm D. Silver
ISBN: 1-58706-076-0
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Chapter authors:
Giorgio Baroldi, Malcolm Silver

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The first need was to reconstruct the natural history of the morphology of the coronary atherosclerotic plaque seen in humans with and without CHD. Since different arterial vessels have dissimilar hemodynamics, wall structure and nervous control, each artery has to be studied independently because the course of the atherosclerotic process could vary, in the aorta, cerebral arteries and coronary arteries. For instance, in a comparative study of 40 hearts with an acute myocardial infarct without cerebral diseases versus 41 cases of brain infarct/ hemorrhage without cardiac diseases, the frequency of a severe stenosis (>=70%) was 88% for coronary arteries and 10% in brain arteries in the first group and 53% and 14% respectively in the second group. Note (a) the very high frequency of severe coronary stenosis in the brain patients without heart disease and (b) the very low frequency of severe obstructions in the cerebral arteries of both groups (Fig. 5; Antoci et al, 1980).

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Chapter category: Heart

Natural History of the Human Coronary Atherosclerotic Plaque and Related Forms of Myocardial Injuries

Additional chapters from this book:

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