Chapter category: Heart
Findings in Acute Coronary Syndromes
The Etiopathogenesis of Coronary Heart Disease:
A Heretical Theory Based on Morphology
Second Edition
Edited by: Giorgio Baroldi and Malcolm D. SilverISBN: 1-58706-076-0
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Chapter authors:
Giorgio Baroldi, Malcolm Silver
In keeping with the “unifying theory”, presented by Gorlin et al 1986, CHD has a common etiopathogenetic denominator, i.e., rupture of an atherosclerotic plaque and consequent thrombosis and/or microembolization and/or spasm. These induce unstable angina, myocardial infarction and sudden death, all included amongst the “acute coronary syndromes”. Thus plaque rupture becomes the center of the CHD universe, with rupture proposed to occur even in small, angiographically undetected plaques (Ambrose et al, 1988). Its prevention, and that alone, will resolve the CHD problem. Our comparative pathological study was programmed to review very old concepts, i.e., whether occlusive coronary thrombosis causes an infarct (Hammer 1878, Herrick 1912, 1919) and whether thrombus plus embolization play a role in CHD (Chapman, 1974; MacIsaac et al, 1993). The following review will compare findings in different groups of CHD and controls, outlining their meaning.
Additional chapters from this book:
Tables and References for the Etiopathogenesis of Coronary Heart Disease
Baroldi, Giorgio, Malcolm Silver
Complete tables and references for the Etiopathogenesis of Coronary Heart Disease.
ILLUSTRATIONS for the Etiopathogenesis of Coronary Heart Disease
Baroldi, Giorgio, Malcolm Silver
Complete Illustrations for this book.
Adrenergic Stress
Baroldi, Giorgio, Malcolm Silver
For millenia mors subita (sudden death) was more a voodoo-religious concept bio-pathologic problem. Cases are reported episodically in ancient writings Phidippides, cited above, who died suddenly cr...
Revisiting Dogma Related to Coronary Artery Disease
Baroldi, Giorgio, Malcolm Silver
Science evolves as a continuous turnover of hypotheses that require constant review/ revision. It is time to reconsider each single caryatid which sustains the present conceptual temple dealing with...
Findings in Acute Coronary Syndromes
Giorgio Baroldi, Malcolm Silver
In keeping with the “unifying theory”, presented by Gorlin et al 1986, CHD has a common etiopathogenetic denominator, i.e., rupture of an atherosclerotic plaque and consequent thrombosis and/or micr...
Natural History of the Human Coronary Atherosclerotic Plaque and Related Forms of Myocardial Injuries
Giorgio Baroldi, Malcolm Silver
The first need was to reconstruct the natural history of the morphology of the coronary atherosclerotic plaque seen in humans with and without CHD. Since different arterial vessels have dissimilar h...
Comparative Pathologic Study
Giorgio Baroldi, Malcolm Silver
The objectives were first to compare the different morphologic variables in acute and chronic coronary syndromes to establish the morpho-functional significance of the changes found in coronary vess...
Plastic Cast Study of Coronary Vessels
Giorgio Baroldi, Malcolm Silver
Coronary heart disease (CHD) becomes epidemic in any society that transforms itself from an agricultural one to an industrial-technological system with an associated behavioural alteration in the po...
