Chapter category: Gene Expression
Cell Cycle Reactivation in Skeletal Muscle and Other Terminally Differentiated Cells
Reactivation of the Cell Cycle in Terminally Differentiated Cells
Edited by: Marco CrescenziISBN: 0-306-47423-9
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Chapter authors:
Alessandra Sacco, Deborah Pajalunga, Lucia Latella, Francesca Siepi, Alessandro Rufini and Marco Crescenzi
This Chapter reviews, in a historical perspective, our current understanding of the cell cycle control in terminally differentiated skeletal muscle cells. Attempts at inducing reentry into the cell cycle and proliferation of terminally differentiated muscle cells are reviewed in this context. The material is deliberately presented from the authors' point of view, providing nonetheless a broad coverage of the contributions of other research groups. Wherever possible, skeletal muscle cells are compared with other terminally differentiated cell types to highlight similarities and differences.
Additional chapters from this book:
Reversal of Terminally Differentiated State in Skeletal Myocytes by SV40 Large T Antigen
Takeshi Endo
Terminal differentiation of mammalian skeletal muscle cells had long been thought to result in irreversible arrest in G0 phase of the cell cycle. Such terminally differe...
Cellular Dedifferentiation During Regeneration: The Amphibian Muscle System
Elly Tanaka
Amphibian limb regeneration represents a striking system where the reversal of muscle cell differentiation occurs in response to physiological stimuli. During this process, dedi...
Cell Cycle Reactivation in Skeletal Muscle and Other Terminally Differentiated Cells
Alessandra Sacco, Deborah Pajalunga, Lucia Latella, Francesca Siepi, Alessandro Rufini and Marco Crescenzi
This Chapter reviews, in a historical perspective, our current understanding of the cell cycle control in terminally differentiated skeletal muscle cells. Attempts at inducing reen...
Regulation of Cardiomyocyte Proliferation and Apoptosis
Kishore B.S. Pasumarthi, Adil I. Daud and Loren J. Field
Myocardial function is compromised in several forms of heart disease due to the loss of cardiomyocytes and in part to the limited ability of surviving myocytes to re–enter the...
Myocyte Proliferation in Heart Failure
Jan Kajstura, Annarosa Leri, Antonio Beltrami, Carlo A. Beltrami, Edmund H. Sonnenblick and Piero Anversa
The results summarized in this short Chapter challenge the perennial dogma that cardiac myocytes are terminally differentiated cells. Unequivocal evidence of mitosis is provided...
