Chapter category: Tissue Engineering

Replacement of Specific Neuronal Populations in the Spinal Cord

This chapter appears in the following book:

Transplantation of Neural Tissue into the Spinal Cord, Second Edition

Edited by: Antal Nogradi
ISBN: 0-387-26355-1
» Get more information about this book at landesbioscience.com «

Chapter authors:
Antal Nogradi

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As discussed in Chapter 5, embryonic spinal cord grafted into the injured spinal cord of neonatal and adult animals can serve as a relay tissue bridge for axonal growth and regeneration, and promote some degree of functional recovery in the host. In these experiments the pattern of host axonal projections to the grafts has been well characterized, but less emphasis has been placed on the efferent connections of the graft. Furthermore, much fewer attempts have been made to look more selectively at the behaviour of specific subpopulations of grafted neurones. At the time of transplantation embryonic spinal cord contains a mixed population of already committed neurones and neuronal precursors which might respond differently to transplantation. In this chapter we will discuss a different experimental approach which explores the possibility of replacing a defined population of the host neurones by homologous cells present in a graft. This approach, focusing on embryonic neurones of a particular type, also provides an interesting opportunity to follow up their fate after grafting.

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Chapter category: Tissue Engineering

Replacement of Specific Neuronal Populations in the Spinal Cord

Additional chapters from this book:

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