Chapter category: Immunology

Fc Receptor Phagocytosis

This chapter appears in the following book:

Molecular Mechanisms of Phagocytosis

Edited by: Carlos Rosales
ISBN: 0-387-25419-6
» Get more information about this book at landesbioscience.com «

Chapter authors:
Randall G. Worth and Alan D. Schreiber

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Antigen recognition by cells of the immune system occurs via many mechanisms. One important family of receptors involved in the recognition of immunoglobulin (Ig) coated particles and complexes are Fc receptors. Fc receptors recognize the Fc portion of Ig and are accordingly grouped into subfamilies. They are named depending upon which class of Ig they bind. The major Fc receptors are Fcg receptors which bind IgG, FcaR that bind IgA and FceR bind IgE.1-4 Fc receptors are responsible for such functions as endocytosis,5-8 phagocytosis, 9-12 granule release,13-17 reactive mediator release and cell activation/cytotoxicity.18-23 Fc receptors are found on specific cell types corresponding to their ability to recognize Ig. For example, Fce receptors are found primarily on eosinophils, basophils and mast cells where they trigger histamine release from intracellular granules whereas Fcg receptors are found primarily on neutrophils, macrophages and monocytes where they can detect and phagocytose IgG coated pathogens.

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Chapter category: Immunology

Fc Receptor Phagocytosis

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