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Chapter category: Reproductive Biology
Spatial and Temporal Regulation of Hair Follicle Progenitors by Hedgehog Signalling
Chapter authors:
Anthony E. Oro
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Epithelial organs such as the vertebrate hair undergo programmed self-renewal in part by
controlling the growth of progenitor cells. The hedgehog signaling pathway regulates
progenitor growth in a variety of tissues. This chapter discusses evidence for how the
skin regulates the production of Shh ligand, the reception of the Shh signal, and maintenance
of the signal to promote hair morphogenesis and prevent tumor formation.
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