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Chapter category: Immunology

Regulation of Phagocytosis by FcgRIIb and Phosphatases

This chapter appears in the following book:

Molecular Mechanisms of Phagocytosis

Edited by: Carlos Rosales
ISBN: 0-387-25419-6
» Get more information about this book at landesbioscience.com «

Chapter authors:
Susheela Tridandapani and Clark L. Anderson


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Phagocytosis of immune-complexes is a dynamic process that is accompanied by the generation of inflammatory/tissue damaging products. Recent advances in the field indicate that this process is subject to regulation by inhibitory Fcg receptors and intracellular phosphatases, including the inositol phosphatases SHIP-1, SHIP-2 and PTEN, and the protein tyrosine phosphatase SHP-1. This chapter will describe the role of the inhibitory Fc receptor, FcgRIIb, and the phosphatases in modulating the signaling events leading to phagocytosis and the accompanying inflammation.

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Additional chapters from this book:

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