Chapter category: Endocrine
Regulation of Parathyroid Hormone Gene Expression by 1,25-Dihydroxyvitamin D
Molecular Biology of the Parathyroid
Edited by: Tally Naveh-ManyISBN: 0-306-47847-1
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Chapter authors:
Tally Naveh-Many and Justin Silver
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Additional chapters from this book:
Skeletal and Reproductive Abnormalities in Pth-Null Mice
Dengshun Miao, Bin He, Beate Lanske, Xiu-Ying Bai, Xin-Kang Tong, Geoffrey N. Hendy, David Goltzman and Andrew C. Karaplis
We have examined the role of parathyroid hormone (PTH) in the postnatal state in a mouse model of PTH-deficiency generated by targeting the Pth gene in ES cells. Mice homozygous for the ablated alle...
Genetic Causes of Hypoparathyroidism
Rachel I. Gafni and Michael A. Levine
Hypoparathyroidism is characterized clinically by the presence of hypocalcemia and hyperphosphatemia due to inadequate supply or effectiveness of circulating parathyroid hormone (PTH). It may be pre...
Molecular Genetic Abnormalities in Sporadic Hyperparathyroidism
Trisha M. Shattuck, Sanjay M. Mallya and Andrew Arnold
The biochemical state of primary hyperparathyroidism is generally caused by hypercellular parathyroid glands categorized as multigland hyperplasia, benign adenoma or malignant carcinoma. Most, and p...
Molecular Mechanisms in Parathyroid Tumorigenesis
Eitan Friedman
Primary hyperparathyroidism (1 HPT) is a relatively common disorder, with an estimated prevalence of 1:500-1:1000.1 In about 80%-85% of 1 HPT cases, a single enlarged parathyroid gland with a distin...
Parathyroid Gland Hyperplasia in Renal Failure
Adriana S. Dusso, Mario Cozzolino and Eduardo Slatopolsky
Secondary hyperparathyroidism, a frequent complication of chronic renal failure, is characterized by parathyroid hyperplasia and enhanced synthesis and secretion of parathyroid hormone (PTH).1-3 As ...
Vitamin D Analogs for the Treatment of Secondary Hyperparathyroidism in Chronic Renal Failure
Alex J. Brown
Secondary hyperparathyroidism (2oHPT) is a common complication in patients with chronic renal failure. The pathogenesis of 2oHPT is attributed primarily to phosphate retention and low serum 1,25(OH)...
Regulation of Parathyroid Hormone Gene Expression by 1,25-Dihydroxyvitamin D
Tally Naveh-Many and Justin Silver
Vitamin D’s active metabolite 1,25(OH)2D3 acts on the parathyroid to markedly decrease PTH gene transcription. It does this by binding to its specific receptor in the parathyroid which then binds ...
In Silico Analysis of Regulatory Sequences in the Human Parathyroid Hormone Gene
Alexander Kel, Maurice Scheer and Hubert Mayer
Parathyroid hormone (PTH) is intimately involved in the homeostasis of normal serum concentrations of calcium and phosphate, which, in turn, regulate the synthesis and secretion of PTH. The synthesi...
Regulation of Parathyroid Hormone mRNA Stability by Calcium and Phosphate
Rachel Kilav, Justin Silver and Tally Naveh-Many
Calcium and phosphate regulate parathyroid hormone (PTH) secretion, gene expression and if prolonged also parathyroid proliferation. The regulation of PTH gene expression by Ca2+ and Pi is post-tran...
The Calcium Sensing Receptor
Shozo Yano and Edward M. Brown
The acute secretory response of parathyroid hormone (PTH) is strictly regulated by the extracellular calcium concentration (Ca2+ o), and the G protein-coupled, calcium-sensing receptor (CaR) locate...
Toward an Understanding of Human Parathyroid Hormone Structure and Function
Lei Jin, Armen H. Tashjian, Jr., and Faming Zhang
Parathyroid hormone (PTH) is synthesized as a 115 amino acid precursor and secreted as an 84 amino acid polypeptide that regulates extracellular calcium homeostasis via actions directly on kidney an...
Parathyroid Hormone, from Gene to Protein
Osnat Bell, Justin Silver and Tally Naveh-Many
The biosynthetic pathway of parathyroid hormone (PTH) has been studied from gene expression to PTH intracellular processing.1 The processing of PTH has been described and involves the synthesis of a...
Development of Parathyroid Glands
Thomas Gunther and Gerard Karsenty
The parathyroid glands (PG) are the main source for circulating parathyroid hormone (PTH), a hormone that is essential for the regulation of calcium and phosphate metabolism. The PGs develop during ...
