Chapter category: Oncology
Estrogen Receptors in Resistance to Hormone Therapy
Breast Cancer Chemosensitivity
Edited by: Dihua Yu and Mien-Chie HungISBN: 978-0-387-74037-9
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Chapter authors:
Matthew H. Herynk and Suzanne A.W. Fuqua
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Matthew H. Herynk
Breast Center, Baylor College of Medicine and the Methodist Hospital
Suzanne A.W. Fuqua
Departments of Medicine, Molecular and Cellular Biology, Breast Center, Baylor College of Medicine
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Estrogen Receptors in Resistance to Hormone Therapy
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Estrogen and its receptors a and b (ERa and ERb) play a major role in tumor progression and approximately two-thirds of breast cancers express these functional receptors. Thus, the ER is a major targe...
p53, BRCA1 and Breast Cancer Chemoresistance
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The tumor suppressor genes p53 and BRCA1 are involved in hereditary as well as sporadic breast cancer development and therapeutic responses. While p53 mutations contribute to resistance to chemo- and ...
