Chapter category: Cell Metabolism
Transport of Lysosomal Enzymes
Lysosomes
Edited by: Paul SaftigISBN: 0-387-25562-1
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Chapter authors:
Stephan Storch and Thomas Braulke
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Additional chapters from this book:
Transport of Lysosomal Enzymes
Stephan Storch and Thomas Braulke
More than 50 acid hydrolases involved in the ordered lysosomal degradation of a variety of proteins, lipids, carbohydrates, and nucleic acids have been identified. The hydrolases are enclosed by a m...
Adaptor Proteins in Lysosomal Biogenesis
P. Schu
Lysosomal membrane proteins and soluble lysosomal proteins are transported from the trans-Golgi network (TGN) to endosomes and lysosomes via coated-vesicles, which bud from the donor compartment and...
Papillomavirus Infections and Cancerogenesis of Squamous Cell and Basal Cell Carcinomas
Guido Bens
Human papillomaviruses (HPVs) are a large group of infectious agents that induce various lesions of skin and mucosae. The carcinogenic role of HPV types 16 and 18, mediated by inactivation of the tu...
Lysosomal Storage Disorders
Ole Kristian Greiner-Tollersrud and Thomas Berg
The lysosomal storage disorders (LSD) are a group of about 50 diseases that are characterised by an accumulation of waste products in the lysosomes, resulting in the formation of large intracellular...
History and Morphology of the Lysosome
Renate Lullmann-Rauch
The lysosome is the cell‘s main digestive compartment to which all sorts of macromol ecules are delivered for degradation. The structure of the lysosome is variable and de pends on the cell type a...
Lysosomal Proteases: Revival of the Sleeping Beauty
Klaudia Brix
Lysosomal proteases belong to the aspartic, cysteine, or serine proteinase families of hydrolytic enzymes. They are expressed ubiquitously, and in a tissue- or cell type-specific manner. Although we...
Lysosomal Membrane Proteins
Paul Saftig
The lysosomal limiting membrane has multiple functions including acidification of the lysosomal matrix, sequestration of lysosomal enzymes, mediation of fusion events beween lysosomes and other orga...
External Lysosomes The Osteoclast and its Unique Capacities to Degrade Mineralised Tissues
Vincent Everts, Wouter Beertsen
Lysosomes contain the enzymatic machinery to digest a host of organic substances. This degrading activity occurs primarily inside the living cell where the lysosomes reside. Yet, some cells use lyso...
Lysosomal Proteome and Transcriptome
Jobst Landgrebe and Torben Lübke
As reflected in this monograph, a lot of knowledge about the lysosomal compartment has been acquired since the discovery of the organelle by de Duve and others in the 1950s. Nevertheless, a lot of q...
Chaperone-Mediated Autophagy
Erwin Knecht* and Natalia Salvador
Many lysosomal and nonlysosomal pathways degrade intracellular proteins and this variety allows all cell proteins to be proteolysed at various speeds in response to different stimuli. Lysosomes, whi...
Membrane Resealing Mediated by Lysosomal Exocytosis
Norma W. Andrews
Ca2+-regulated exocytosis was proposed to mediate plasma membrane repair , but until recently the nature of the vesicles involved was unknown. Recent work from our labo ratory identified lysosomes a...
Neuronal Ceroid-Lipofuscinoses
Jaana Tyynela
Neuronal ceroid-lipofuscinoses (NCLs, also referred to as Batten’s disease) are inherited lysosomal storage diseases characterized by progressive neurodegeneration and premature death. As a group,...
Therapy of Lysosomal Storage Diseases
Ulrich Matzner
Lysosomes are membrane-surrounded organelles which are present virtually in all animal cells. They function to degrade both intra- and extracellular macromolecules to low molecular components that a...
Macroautophagy in Mammalian Cells
Eeva-Liisa Eskelinen
Autophagy is a lysosomal degradation pathway for cytoplasmic material, which is activated during stress conditions such as amino acid starvation or viral infection. Yeast mutants defective in autoph...
