Chapter category: Infectious Disease
Thinking Transgenic Vectors in a Population Context: Some Expectations and Many Open-Questions
Genetically Modified Mosquitoes for Malaria Control
Edited by: Christophe BoëteISBN: 1-58706-096-5
» Get more information about this book at landesbioscience.com «
Chapter authors:
Christine Chevillon, Richard E. Paul, Thierry de Meeus, François Renaud
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Additional chapters from this book:
Transgenic Mosquitoes for Malaria Control: Time to Spread Out of the Scientific Arena
Christophe Boëte
The release of mosquitoes that are genetically modified to destroy the malaria parasite Plasmodium falciparum is being considered as a possible method for malaria control. If many scientific que...
Predicting the Spread of a Transgene in African Malaria Vector Populations: Current Knowledge and Limitations
Frédéric Simard and Tovi Lehmann
One strategy for the control of malaria and other vector-borne diseases relies on the ambitious goal of depleting natural vector populations’ ability to transmit the pathogen through the introduct...
Everything (or Almost Everything) You Want to Know about Genetically Modified Mosquitoes for Malaria Control but Are (Maybe) Afraid to Ask
Christophe Boëte
This chapter is a brief introduction to the book “Genetically Modified Mosquitoes for Malaria Control”....
The Genetics of Vector-Host Interactions: Alternative Strategies for Genetic Engineering for Malaria Control
Willem Takken and Carlo Costantini
Malaria transmission is accomplished by the innate behavioural trait of mosquitoes to ingest vertebrate blood required for egg production. As human malaria parasites are, by definition, circulatin...
Malaria-Refractoriness in Mosquito: Just a Matter of Harbouring Genes?
Christophe Boëte
Amongst the last vector-based hopes for malaria control and possibly the most touted is, without doubt, the use of transgenic mosquitoes able to kill/ block the development of malaria parasites an...
Malaria Situation in the Beginning of the 2Ist Century
Mahamadou A. Théra, Abdoulaye A. Djimdé, Alassane Dicko, Mahamadou Diakité, Kassoum Kayentao, Boubacar Traoré, Amagana Dolo and Ogobara K. Doumbo
Falciparum malaria parasite an avian originated parasite has probably coevolved with human being (Homo sapiens) since the discovery of agriculture, around 20-30 000 years ago. The very devastating...
Advantages and Limitations of Transgenic Vector Control: Sterile Males versus Gene Drivers
Christopher Curtis, Paul G. Coleman, David W. Kelly and Diarmid H. Campbell-Lendrum
Transgenesis might be used to produce fitter and more acceptable sterile males than those hitherto produced with radiation or chemosterilants. It is possible to engineer a dominant lethal constr...
Genetically-Modified Mosquitoes for Malaria Control: Requirements to be Considered Before Field Releases
Yeya T. Touré and Bart G.J. Knols
The technical feasibility of the development of transgenic mosquitoes highly refractory to (rodent) malaria parasites has been demonstrated in the laboratory. Following this proof of principle, geneti...
The Epidemiological Consequences of Reducing the Transmission Intensity of P. falciparum
Hugh Reyburn and Chris Drakeley
Control methods which aim to reduce the human host’s exposure to infected mosquitoes (as is the desired outcome of a release of transgenic mosquitoes) will ideally reduce the frequency of malarial i...
Malaria Parasite Virulence in Mosquitoes and Its Implications for the Introduction and Efficacy of GMM Malaria Control Programmes
Heather Ferguson, Sylvain Gandon, Margaret Mackinnon and Andrew Read
Initial scepticism about the ecological feasibility of the genetically modified mosquito (GM) approach for malaria control1,2 has been supported by some recent experimental studies indicating that the...
Immune System Polymorphism Implications for Genetic Engineering
Tom J. Little
As is apparent from the evolution of antibiotic resistance or vaccine escape mutants, parasites and pathogens have the capacity to repeatedly evolve adaptations which enable them to overcome medical...
Malaria and Structural Adjustment: Proof by Contradiction
Julie Castro and Damien Millet
The evolution of malaria over the last thirty years shows that far from regressing, the disease is actually in a process of reglobalisation. While health institutions confine them selves to analysin...
Ethics and Community Engagement for GM Insect Vector Release
Darryl Macer
The ethical, social and legal issues raised by the release of genetically modified insect vectors in public health need to be considered in depth at an early stage in the development of protocols to...
Thinking Transgenic Vectors in a Population Context: Some Expectations and Many Open-Questions
Christine Chevillon, Richard E. Paul, Thierry de Meeus, François Renaud
The present papers tries to place questions regarding the eventual release of transgenic Plasmodium-resistant mosquitoes within an overall population context. This means a context that is not limite...
Development of a Toolkit for Manipulating Malaria Vectors
Flaminia Catteruccia, Anthony E. Brown, Elisa Petris, Christina Scali and Andrea Crisanti
This chapter will review the efforts made by several laboratories to generate in Anopheles mosquitoes a variety of molecular tools, similar to those available to the Drosophila community, to exploit...
