Chapter category: Development
Hedgehog Signalling in T Lymphocyte Development
Shh and Gli Signaling and Development
Edited by: Carolyn E. Fisher and Sarah E.M. HowieISBN: 0-387-39956-9
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Chapter authors:
Susan Outram*, Ariadne L Hager-Theodorides and Tessa Crompton
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Additional chapters from this book:
Sonic Hedgehog Signaling in Craniofacial Development
Dwight Cordero, Minal Tapadia and Jill A. Helms
Facial malformations comprise a significant proportion of the anomalies observed in children born with birth defects. Although congenital facial disfigurements are relatively common and have been ex...
Hedgehog Signalling in T Lymphocyte Development
Susan Outram*, Ariadne L Hager-Theodorides and Tessa Crompton
T cell development occurs in the thymus, which is seeded by multipotential lymphocyte progenitor cells. These cells then move through a sequence of clearly defined developmental stages at the end of...
Role of Hedgehog and Gli Signalling in Telencephalic Development
Paulette A. Zaki, Ben Martynoga and David J. Price
Studies performed over the last decade have significantly increased our understanding of the role of Hedgehog (Hh) signalling in brain development. Here, we review the various in vitro and in vivo s...
Sonic Hedgehog Signaling in Visceral Organ Development
Huimin Zhang, Ying Litingtung and Chin Chiang
The secreted signaling molecule encoded by Sonic hedgehog (Shh) has been shown to play an indispensable role in mammalian organogenesis. During embryonic development, one of the prominent sites of S...
Sonic Hedgehog Signaling in the Developing and Regenerating Fins of Zebrafish
Fabien Avaron, Amanda Smith and Marie-Andre Akimenko
Zebrafish is now a well established model for the study of developmental and regenerative processes. Indeed, the genetic cascades that control the early development of the structure that will form t...
Upstream and Downstream of Shh Signalling
Aimee Zuniga and Antonella Galli
The vertebrate limb is an attractive model system for studying the interplay of signalling molecules that coordinate growth and patterning during organogenesis. Sonic Hedgehog (Shh) plays a key regu...
Hedgehog Signalling in Prostate Morphogenesis
Marilyn L. G. Lamm* and Wade Bushman
The prostate gland has not traditionally been a popular model system in developmental biology, and mechanistic studies of prostate morphogenesis have generally lagged behind work in other well-chara...
Role of Shh and Gli Signalling in Oligodendroglial Development
Min Tan, Yingchuan Qi and Mengsheng Qiu
Recent molecular and genetic studies have demonstrated that early oligodendrocyte progenitor cells are induced from the ventral neural tube by the Sonic hedgehog (Shh) protein produced in the ventra...
New Perspectives in Shh Signalling?
Carolyn Fisher
The Shh-Ptc signalling pathway and its components have been the subject of much research. Previous chapters of this book have illustrated the importance of this pathway and its activation in many as...
Sonic Hedgehog Signalling during Tooth Morphogenesis
Martyn T. Cobourne, Isabelle Miletich and Paul T. Sharpe
The Sonic hedgehog (Shh) peptide belongs to a small family of signalling molecules that have a complex mode of action and wide range of function during normal vertebrate development. In common with ...
Multiple Roles for Hedgehog Signaling in Zebrafish Eye Development
Deborah L. Stenkamp
The Hedgehog signaling pathway is important in a large number of developmental contexts. In this review, several functions of this pathway for vertebrate eye formation and differentiation will be di...
INTRODUCTION
Carolyn E. Fisher and Sarah E.M. Howie
Although no real insights into the mechanisms of development were obtained until after 1880, when experimental approaches to embryology were established, descriptive studies of embryo development ha...
Sonic Hedgehog Signalling in Dorsal Midline and Neural Development
Silvia L. Lopez and Andres E. Carrasco
Sonic hedgehog is a secreted morphogen involved in patterning of a variety of structures and organs in vertebrates. In this chapter we focus on its role in the development of the floor plate and in ...
Shh/Gli Signaling During Murine Lung Development
Martin Rutter and Martin Post
Murine lung development is a complex process regulated by many factors guiding a carefully orchestrated series of events leading to mature lung formation. Many developmental pathways have been impli...
