Chapter category: Gene Therapy
Rb and Cellular Differentiation
Rb and Tumorigenesis
Edited by: Maurizio FanciulliISBN: 0-387-32173-X
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Chapter authors:
Lucia Latella and Pier Lorenzo Puri*
The pivotal role of the Retinoblastoma gene product p110 (pRb) in cellular differentiation has been postulated since the identification of pRb as a target of oncogenic events.1-3 The demonstration of the essential role of pRb during terminal differentiation of many tissues appeared evident along with the identification of the critical properties of pRb in regulating cell cycle progression and apoptosis.4-6 Permanent cell cycle arrest and resistance to both tumor formation and apoptosis are three cardinal features of terminal differentiation.7-11 Upon functional or genetic inactivation of pRb, cells from skeletal muscle, neuronal and hematopoietic lineages exhibit higher extent of apoptosis, fail to permanently exit the cell cycle and show incomplete differentiation.
Additional chapters from this book:
Rb and Cellular Differentiation
Lucia Latella and Pier Lorenzo Puri*
The pivotal role of the Retinoblastoma gene product p110 (pRb) in cellular differentiation has been postulated since the identification of pRb as a target of oncogenic events.1-3 The demonstration o...
Regulation of Rb Function by Noncyclin Dependent Kinases
Jaya Padmanabhan and Srikumar P. Chellappan
Inactivation of the retinoblastoma tumor suppressor protein, Rb, is necessary for the normal progression of the mammalian cell cycle.1 Studies over the past fifteen years have shown that Rb protein ...
Regulation of E2F-Responsive Genes through Histone Modifications
Estelle Nicolas, Laetitia Daury and Didier Trouche
The retinoblastoma protein Rb, when targeted to E2F-responsive promoters through a direct interaction with E2F proteins, actively represses transcription. This property is shared by the two Rb-relat...
Regulation of DNA Replication by the Retinoblastoma Tumor Suppressor Protein
Erik S. Knudsen and Steven P. Angus
The retinoblastoma gene product (RB) plays a critical role in the inhibition of cancer. This prototypical tumor suppressor was identified based on bi-alleleic inactiviation in the pediatric tumor re...
pRb in the Differentiation of Normal and Neoplastic Cells
Deborah Pajalunga, Grazia Camarda and Marco Crescenzi
This chapter deals with the role played by the retinoblastoma protein (pRb) in a variety of differentiation processes. After broadly reviewing the current knowledge on this issue, it points at two c...
RB as Positive Transcriptional Regulator During Epithelial Differentiation
Chantal E. Cremisi and Linda L. Pritchard
RB plays an essential role in epithelial cell differentiation and viability, these two properties being totally linked and independent of p53. To exert these functions, RB acts as a positive transcr...
Diverse Regulatory Functions of the E2F Family of Transcription Factors
Fred Dick and Nick Dyson
E2F activity is largely controlled by cell cycle dependent phosphorylation of the Retino blastoma family of proteins (eg. pRB). Regulation of E2F transcription factors by RB-family proteins is cruci...
Emerging Roles for the Retinoblastoma Gene Family
Jacqueline L. Vanderluit, Kerry L. Ferguson and Ruth S. Slack
Research on the retinoblastoma protein has grown from studying its role as a tumour suppressor in cancer to identifying it as a key regulator of the cell cycle G1/S check point and today to explorin...
New Insights Into Transcriptional Regulation by RB: One Size No Longer Fits All
Peggy J. Farnham
The retinoblastoma (Rb) protein is a key regulator of cell proliferation, differentiation, and tumorigenesis. Initial studies of Rb revealed that it binds to, and decreases the activity of, the E2F ...
