A New Member of the CtBP/BARS Family from Plants: Angustifolia

Hirozaku Tsukaya

The ANGUSTIFOLIA (AN) gene in Arabidopsis thaliana (L.) Heynh. is the first \r\nhomolog of the CtBP/BARS gene family identified in plants and is responsible for the polarity-dependent control of leaf ...

CtBP Family Proteins: Unique Transcriptional Regulators in the Nucleus with Diverse Cytosolic Functions

G. Chinnadurai

CtBP family proteins are unique in animals and in plants. The invertebrates and plants contain a single CtBP family gene while vertebrates have two genes. Genetic studies in Drosophila and in mice ind...

CtBP Corepressor Complex - A Multi-Enzyme Machinery that Coordinates Chromatin Modifications

Recent biochemical and proteomic approach has identified a CtBP super complex consisting of a host of chromatin modifying enzymes. Analysis of this complex has led to the appreciation that enzymes tha...

The Significance of the CtBP: AdE1A Interaction during Viral Infection and Transformation

Roger J.A. Grand, Claire Baker, Paola M. Barral, Rachel K. Bruton, Julian Parkhill, Tadge Szestak and Philip H. Gallimore

C-terminal binding protein (CtBP) associates with adenovirus early region 1A (AdE1A) proteins through a highly conserved PXDLS motif located very close to its C-terminus in conserved region 4. To try ...

CtBP Proteins in Vertebrate Development

Jeffrey D. Hildebrand

The fundamental question facing developmental biology is how the diversity of cell and tissue types that comprise a vertebrate organism can be generated from a single fertilized egg. A critical aspect...

CtBPs as Synaptic Proteins

Susanne tom Dieck, Frank Schmitz and Johann Helmut Brandstätter

A surprising new aspect of CtBP family proteins arose from the identification of a novel CtBP protein named RIBEYE.1 RIBEYE, which consists of a unique amino-terminal A-domain and a carboxy-terminal B...

CtBP3/BARS and Membrane Fission

Stefania Spanò, Cristina Hidalgo Carcedo and Daniela Corda

CtBP3/BARS was the third protein of the CtBP (C-terminal binding protein) family to be identified. It was initially isolated as a 50-kDa cytosolic protein during the characterisation of the molecular ...

CtBP: A Link between Apoptosis and the Epithelial-Mesenchymal Transition

Steven M. Frisch

Adenovirus E1a proteins are potent and ubiquitously acting tumor suppressors in human tumor cells. Through interaction with CtBP (as well as other mechanisms), E1a protein sensitizes cells to several ...

CtBP and Hematopoietic Transcriptional Regulators

Alexis Verger, Jose Perdomo and Merlin Crossley

The C-terminal binding proteins (CtBPs) are ubiquitous corepressors that recruit histone-modifying enzymes to a variety of sequence specific DNA-binding proteins and other transcriptional regulators. ...

CtBP as a Redox Sensor in Transcriptional Repression

Qinghong Zhang, Clark C. Fjeld, Amanda C. Nottke and Richard H. Goodman

The corepressor CtBP (carboxyl-terminal binding protein) is involved in transcriptional pathways important for development, cell cycle regulation, and transformation. We demonstrate that CtBP binding ...

Transcriptional Repression by the CtBP Corepressor in Drosophila

Hitoshi Aihara, Lorena Perrone and Yutaka Nibu

Transcriptional repression is essential for patterning gene expression in the early Drosophila embryo. Biochemical and genetic studies on Drosophila C-terminal binding protein (dCtBP) have provided so...

Structural Determinants of CtBP Function

James R. Lundblad

The structural characteristics of the CtBP family of transcriptional corepressors suggest an additional role for coenzyme nicotinamide adenine dinucleotide in the repression of gene expression. Remark...