Chapter category: Gene Expression
Analytical Evolutionary Model for Protein Fold Occurrence in Genomes, Accounting for the Effects of Gene Duplication, Deletion, Acquisition and Selective Pressure
Chapter authors:
Michael Kamal, Nicholas M. Luscombe, Jiang Qian and Mark Gerstein*
Global surveys of protein folds in genomes measure the usage of essential molecular parts in different organisms. In a recent survey, we showed that the occurrence of protein folds in 20 completely sequence genomes follow a power-law distribution; i.e., the number of folds (F) with a given genomic occurrence (V) decays as F (V )= aV -b, with a few occurring many times and most occurring infrequently. Clearly, such a distribution results from the way in which genomes have evolved into their current states.
