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Chapter category: Development

Neural Crest Delamination and Migration: Integrating Regulations of Cell Interactions, Locomotion, Survival and Fate

This chapter appears in the following book:

Neural Crest Induction
and Differentiation

Edited by: Jean-Pierre Saint-Jeannet
ISBN: 0-387-35136-1
» Get more information about this book at landesbioscience.com «

Chapter authors:
Jean-Loup Duband


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During the entire process of neural crest development from specification till final differentiation, delamination and migration are critical steps where nascent crest cells face multiple challenges: within a relatively short period of time that does not exceed several hours, they have to change drastically their cell- and substrate-adhesion properties, lose cell polarity and activate the locomotory machinery, while keeping proliferating, surviving and maintaining a pool of precursors in the neural epithelium. Then, as soon as they are released from the neural tube, neural crest cells have to adapt to a new, rapidly-changing environment and become able to interpret multiple cues which guide them to appropriate target sites and prevent them to distribute in aberrant locations. It appears from recent studies that, behind an apparent linearity and unicity, neural crest development is subdivided into several independent steps, each being governed by a multiplicity of rules and referees. Here resides probably one of the main reasons of the success of neural crest cells to accomplish their task.

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Additional chapters from this book:

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