Chapter category: Signal Transduction
TRAF Proteins in CD40 Signaling
TNF Receptor Associated Factors (TRAFs)
Edited by: Hao WuISBN: 978-0-387-70629-0
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Chapter authors:
Gail A. Bishop, Carissa R. Moore, Ping Xie, Laura L. Stunz and Zachary J. Kraus
The tumor necrosis factor receptor (TNFR) superfamily molecule CD40 is expressed by a wide variety of cell types following activation signals, and constitutively on B lymphocytes, macrophages, and dendritic cells. CD40 signals to cells stimulate kinase activation, gene expression, production of a antibody and a variety of cytokines, expression or upregulation of surface molecules, and protection or promotion of apoptosis. Initial steps in CD40-mediated signal cascades involve the interactions of CD40 with various members of the TNFR-associated factor (TRAF) family of cytoplasmic proteins. This review summarizes current understanding of the nature of these interactions, and how they induce and regulate CD40 functions.
Gail A. Bishop
Departments of Microbiology and Internal Medicine, Interdisciplinary Graduate Program in Immunology, University of Iowa; Iowa City VAMC
Carissa R. Moore
Interdisciplinary Graduate Program in Immunology, University of Iowa
Ping Xie
Department of Microbiology, University of Iowa
Laura L. Stunz
Department of Microbiology, University of Iowa
Zachary J. Kraus
Interdisciplinary Graduate Program in Immunology, University of Iowa
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