Chapter category: Development
Integrins: An Overview of Structural and Functional Aspects
Integrins and Development
Edited by: Erik H.J. DanenISBN: 1-58706-293-3
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Chapter authors:
Erik H. J. Danen
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Additional chapters from this book:
Integrin Regulation of Mammary Gland Development
Matthew J. Naylor and Charles H. Streuli
The interaction between a cell and its microenvironment is critical in governing cellular function. Integrins, the major family of extracellular matrix receptors, link the matrix with the actin cyto...
Integrins: An Overview of Structural and Functional Aspects
Erik H. J. Danen
Integrins are heterodimeric transmembrane receptors that mediate cell-adhesion.1 With their extracellular head region, most integrins bind extracellular matrix (ECM) glycoproteins such as laminins a...
The Role of Integrins in Cell Migration
Bernhard Wehrle-Haller
Migration and Motility are essential components of the behavioral repertoire of a cell. During embryogenesis cells move in sheets or loosely attached populations to create complex tissues. In the adul...
Integrins in Urogenital Development
Jordan A. Kreidberg
The urogenital system is a complex system composed of multiple organs, most notably the kidneys and gonads, as well as many other glandular components and connective tissues. This review will concentr...
Cell Adhesion in Nervous System Development:
Claudia S. Barros and Ulrich Müller
Integrins are a family of cell surface receptors that are expressed in many if not all tissues. Integrins mediate interactions with different ligands including extracellular matrix glyco- proteins,...
Insights into Integrin Function in Skeletal Muscle
Lisa K. Rogers and Ulrike Mayer
Skeletal muscle accounts for 40% of the human body and is the major consumer of body fuels. Contraction within muscle fibers by ATP consumption generates the force required for our body movement, bu...
The Role of Integrins in Vasculogenesis and Angiogenesis
Andrew R. Reynolds, Kate A. Scott and Kairbaan M. Hodivala-Dilke*
This chapter aims to summarise the current literature regarding the role of integrins in blood vessel growth. Blood vessels arise via vasculogenesis and angiogenesis and we begin by giving a brief i...
Integrins in the Skin
Cord Brakebusch
The skin protects the body of mammalians from mechanical and chemical damage, is a barrier against infections and prevents dehydration. It can be divided into an upper layer, called epidermis, and a...
Roles for Integrins and Associated Proteins in the Haematopoietic System
Alessandra Cambi, Suzanne F.G. van Helden and Carl G. Figdor
The haematopoietic system is a highly dynamic system where cell adhesion and cell migration are tightly controlled. During both embryonic and adult haematopoiesis, the finely orchestrated action of ...
Integrins and Associated Proteins in Drosophila Development
Maithreyi Narasimha and Nicholas H. Brown
We discuss insights into integrin function obtained through phenotypic and structure function analysis of integrins and associated proteins in the fruitfly, Drosophila melanogaster. Integrins contri...
Integrins in Skeletal Cell Function and Development
Michael A. Horton and Miep H. Helfrich
Genes for 18 ? and 8 ? integrin subunits have been identified in vertebrates, their protein products associating into 24 different heterodimeric membrane receptors. Skeletal cells – osteoclasts, ost...
The Essence of Integrin Signal Transduction:Assembly of Dynamic Scaffolds and Cross-Talk with Other Receptors
Sara Cabodi and Paola Defilippi
Integrin signalling has a critical function in organizing cells in tissues during both embryonic development and tissue repair. Following their binding to the extracellular ligands, the intracellula...
Integrins in Extracellular Matrix Assembly
Roumen Pankov and Katherine Clark
Integrin receptors are used by cells not only to bind, but also to actively organize extracellular matrices. They contribute in the in vivo polymerization of the major matrix constituents – fibronec...
C. elegans Integrins
Michel Labouesse and Elisabeth Georges-Labouesse
C. elegans has only one beta integrin chain, called PAT-3, and two alpha integrin chains, called PAT-2 and INA-1. C. elegans integrins are essential for muscle anchoring to the epidermis, cell migra...
