Chapter category: Signal Transduction
TRAF1 and Its Biological Functions
TNF Receptor Associated Factors (TRAFs)
Edited by: Hao WuISBN: 978-0-387-70629-0
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Chapter authors:
Soo Young Lee and Yongwon Choi
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Soo Young Lee
Division of Molecular Life Sciences and Center for Cell Signaling Research, Ewha Womans University
Yongwon Choi
Department of Pathology and Laboratory Medicine, Abramson Family Center Research Institute, University of Pennsylvania School of Medicine
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Tumor necrosis factor (TNF) receptor-associated factor (TRAF)1 was originally identified based on its ability to interact with the cytosolic domain of TNF receptor type 2 (TNFR2). TRAF1 is unique ...
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TNF-receptor-associated factors (TRAFs) are intracellular proteins that bind to the cytoplasmic portion of TNF receptors and mediate downstream signaling. The six known TRAF proteins play overlapping ...
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