Chapter category: Oncology
Thermotherapy and Nanomedicine: Between Vision and Reality
Hyperthermia in Cancer Treatment:
A Primer
Edited by: Gian Franco Baronzio and Erich Dieter HagerISBN: 0-387-33440-8
» Get more information about this book at landesbioscience.com «
Chapter authors:
Andreas Jordan
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Additional chapters from this book:
Locoregional Hyperthermia
E. Dieter Hager
Locoregional hyperthermia can be differentiated into external, interstitial and endocavitary hyperthermia. Different heat delivery systems are available: antennae array, capacitive coupled, and in...
Tumor Ablation Using Radiofrequency Energy: Technical Methods and Application on Liver Tumors
Johannes-Marcus Hänsler, Luigi Solbiati, E. Dieter Hager, Tiziana Ierace, Luca Cova and Gianfranco Baronzio
Radiofrequency ablation is used for the treatment of a variety of neoplasms including: osteoid osteoma, hepatocellular carcinoma, renal cell carcinoma, bronchopulmonary carcinoma, parathyroid aden...
Intracavitary Hyperthermic Perfusion
E. Dieter Hager
Direct intra-peritoneal (IP) installation of anticancer agents for the treatment of patients with peritoneal carcinomatosis or sarcomatosis has pharmacological advantages compared to intravenous syste...
Cytoreduction, Peritonectomy and Hyperthermic Antiblastic Peritoneal Perfusion for the Treatment of Peritoneal Carcinomatosis
Michele De Simone* and Marco Vaira
Peritoneal carcinomatosis may present as synchronous disease or like evolution of gastrointestinal or female genital tumors (including pseudomyxoma peritonei, a variable malignancy myxoid tumor, a...
Fever, Pyrogens and Cancer
Ralf Kleef* and E. Dieter Hager
The observation, that cancer patients who experienced a feverish period after surgery survived significantly longer than patients without fever and the fact, that spontaneous tumor remission was o...
Thermotherapy and Nanomedicine: Between Vision and Reality
Andreas Jordan
Although nanoparticles have been already applied on patients in clinical trials, generally nanotechnology in medicine is regarded rather a vision than a realistic option. Progress in this field ar...
Whole Body Hyperthermia at 43.5-44?C: Dreams or Reality?
Alexey V. Suvernev, Georgy V. Ivanov, Anatoly V. Efremov and Roman Tchervov
A high level of body temperature (43?C) is needed for effective use of whole body hyperthermia. Such high level hyperthermia can only be safely used, taking into account a theory of developing post-...
Thermo-Chemo- Radiotherapy Association: Biological Rationale, Preliminary Observations on Its Use on Malignant Brain Tumors
GianFranco Baronzio,* Vincenzo Cerreta, Attilio Baronzio, Isabel Freitas, Marco Mapelli and Alberto Gramaglia
This review focuses on the biological rationale and the advantages for combining hyperthermia radiotherapy and chemotherapy. Other clinical aspects such as sequence of administration, effects on dru...
Future Perspectives of Interstitial and Perfusional Hyperthermia
Gian Franco Baronzio,* Michele De Simone, Gianmaria Fiorentini, Salvatore D’Angelo, Giovanni Visconti and E. Dieter Hager
Recent developments in thermal ablation and perfusion hyperthermia have expanded the treatment options of patients with certain cancer. Initially thermal ablation was applied to liver tumor, later i...
Physical Background and Technical Realizations of Hyperthermia
Andras Szasz,* Oliver Szasz and Nora Szasz
Hyperthermia is a medical heat-treatment, widely used in various medical fields and has a well-recognized effect in oncology. It is an ancient treatment. However, when making hyperthermia we are lim...
Effects of Local and Whole Body Hyperthermia on Immunity
Gian Franco Baronzio,* Roberta Della Seta, Mario D’Amico, Attilio Baronzio, Isabel Freitas, Giorgio Forzenigo, Alberto Gramaglia and E. Dieter Hager
“Around every tumor there is a patient” – Black, Natl Cancer Inst. Monogr. 1972; 35:276. Abstract In this review, we summarized the historical and experimental basis of cancer immunity and th...
Hyperthermic Isolated Limb Perfusion
Michele De Simone* and Marco Vaira
In this overview we describe surgical procedures and hypertermic-isolated limb perfusion technique for the treatment of in transit metastases from melanoma and sarcoma of the limbs. We also briefly ...
Extreme Whole-Body Hyperthermia with Water-Filtered Infrared-A Radiation
Alexander von Ardenne and Holger Wehner
The testing of various methods to realise extreme whole-body hyperthermia (eWBH) finally led to the utilisation of radiative systems. Among these the application of water-filtered infrared-A radiati...
Vascular Effects of Localized Hyperthermia
Debra K. Kelleher and Peter Vaupel
When hyperthermia is applied in vitro, no fundamental differences can be seen between the response to normal and tumor cells. In vivo however, selective damage of tumor cells can be achieved and thi...
Influence of Tumor Microenvironment on Thermoresponse: Biologic and Clinical Implications
Gian Franco Baronzio, Alberto Gramaglia, Attilio Baronzio and Isabel Freitas
Solid tumours tend to have a more acidic and hypoxic microenvironment than normal tissue. This hostile microenvironment results from a disparity between oxygen supply and demand of the tumor tissue....
A Step Deep on Hyperthermia, Hypoxia and Chemotherapy Interactions
Giammaria Fiorentini,* Ugo De Giorgi, Maurizio Cantore, Andrea Mambrini and Stefano Guadagni
Cancer physiology can be a new significant target for therapy. Nonsurgical approaches to cancer treatment, primarily radiation therapy and chemotherapy, are almost exclusively based on agents that k...
Hyperthermia, Physics, Vector Potential, Electromagnetic Heating: A Primer
Ugo Cerchiari
Heating methodologies of restricted and specific body volumes as means to treat cancer are critically examined from the physical point of view. Difficulties in the application of heating methodologi...
Hyperthermia and Radiotherapy in the Management of Prostate Cancer
Sergio Villa
Carcinoma of the prostate has been included in the top five big killer neoplasms at today. The management of advanced disease is still a problem in oncology. Starting from the begging of eighties, h...
Hyperthermia and Angiogenesis: Results and Perspectives
Cristina Roca and Luca Primo
Hyperthermia (HT) is a promising method for cancer treatment when combined with radiotherapy or chemotherapy. The molecular mechanisms of anti-tumoral efficacy of HT are not well understood. Besides...
Thermometry: Clinical Aspects and Perspectives
Barbara Biaotto and Piergiorgio Marini
Inadequate thermal dose received by the tumor can cause failures in hyperthermic treatments. In order to compare different treatments and to correlate the treatment data with the clinical results, i...
Results of Hyperthermia Alone with Radiation Therapy and/or Chemotherapy
Pietro Gabriele and Cristina Roca
The interest in Clinical Hyperthermia (HT) was maximum in eighties and decreases during nineties of the last century but now, thank to possibility of heat deeply and to measure the temperature not i...
On the Biochemical Basis of Tumour Damage by Hyperthermia
P. Pietrangeli and B. Mondovi
Tumour cells are selectively inhibited by hyperthermia (41-42.5¡C) in the same conditions where normal cells are not damaged. At higher temperature, also normal cells are injured. In spite of the la...
