Chapter category: Neuroscience
The Role of Cyclic Nucleotides in Axon Guidance
Axon Growth and Guidance
Edited by: Dominique BagnardISBN: 978-0-387-76714-7
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Chapter authors:
Michael Piper, Francis van Horck and Christine Holt
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Michael Piper
Francis van Horck
Christine Holt
Department of Anatomy, University of Cambridge
Additional chapters from this book:
Slits and Their Receptors
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Slit was identified in Drosophila embryo as a gene involved in the patterning of larval cuticle. It was later shown that Slit is synthesized in the fly central nervous system by midline glia cells. Sl...
The Role of Cell Adhesion Molecules in Axon Growth and Guidance
Hiroyuki Kamiguchi
During development, axons elongate along the correct path toward their final targets. Growing axons maintain adhesive interactions with specific environmental cues via cell adhesion molecules (CAMs). ...
Membrane Lipid Rafts and Their Role in Axon Guidance
Carmine Guirland and James Q. Zheng
The plasma membrane of cells contains a variety of lipid and protein molecules that are often segregated and heterogeneously distributed in microdomains. Lipid rafts represent a generalized concept of...
The Role of Cyclic Nucleotides in Axon Guidance
Michael Piper, Francis van Horck and Christine Holt
During the formation of the nervous system, axonal growth cones navigate through the complex environment of the developing embryo to innervate their targets. Growth cones achieve this formidable feat ...
Neurotrophic Factors: Are They Axon Guidance Molecules?
Sarah Guthrie
Neurotrophic factors play a multiplicity of roles during development. They can promote axonal growth in vitro and are capable of orienting axons. Recently, molecular evidence suggests that neurotrophi...
Eph Receptors and Ephrin Ligands in Axon Guidance
Michael Reber, Robert Hindges and Greg Lemke
The Eph tyrosine kinase receptors (a receptor family named for the expression of Eph in an erythropoietin-producing human hepatocellular carcinoma cell line) make up the largest family of receptor tyr...
Molecular Mechanisms of Axonal Growth
Céline Bouquet and Fatiha Nothias
Outgrowth of axons during neuronal development, as well as their regeneration after injury, of the adult nervous system is controlled by specific extracellular cues, which are diffusible, or bound to ...
Neurotransmitters and the Development of Neuronal Circuits
Tina Reudiger and Juergen Bolz
In the mature brain, neurotransmitters are used for synaptic communication between neurons. But during nervous system development, neurons often express and release trans-mitters before their axons es...
Netrins and Their Receptors
Simon W. Moore, Marc Tessier-Lavigne and Timothy E. Kennedy
Netrins are a family of proteins that direct cell and axon migration during development. Three secreted netrins (netrin-1, -3 and -4) have been identified in mammals, in addition to two GPI-anchored m...
The Role of Glial Cells in Axon Guidance, Fasciculation and Targeting
Anabel R. Learte and Alicia Hidalgo
Axons navigate step-wise, from one intermediate target to the next, until they reach their final destination target. In the central nervous system, intermediate targets are often glial cells, and fina...
Role of Semaphorins during Axon Growth and Guidance
Eric Koncina, Lise Roth, Bertand Gonthier and Dominique Bagnard
During development, neuronal growth cones navigate over long distances to reach their target and establish appropriate connections. This process is usually described as a step by step mechanism of gro...
The Hedgehog, TGF-b/BMP and Wnt Families of Morphogens in Axon Guidance
Frederic Charron and Marc Tessier-Lavigne
During embryonic development, morphogens act as graded positional cues to dictate cell fate specification and tissue patterning. Recent findings indicate that morphogen gradients also serve to guide a...
