Chapter category: Signal Transduction

Abelson Family Protein Tyrosine Kinases and the Formation of Neuronal Connectivity

This chapter appears in the following book:

Abl Family Kinases in Development
and Disease

Edited by: Anthony J. Koleske
ISBN: 0-387-36640-7
» Get more information about this book at landesbioscience.com «

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The nervous system is an organ of immense complexity. Neural function and the integration of neural input depend upon the formation of an intricate network of synaptic connections. Building this neural architecture during development involves several aspects of neuronal morphogenesis, from neuronal polarization and the extension of neuronal processes, to the pathfinding of axons across long distances to appropriate target cells and the elaboration of dendritic arbors, resulting in the assembly and maintenance of synapses between each neuron and its targets. Each neuronal subclass relies upon multiple extracellular cues to direct its pathfinding and synaptogenesis to the correct locations within the developing embryo. While much progress has been made in the identification of the extracellular factors and corresponding cell surface receptors that control these aspects of neuronal differentiation, much less is known about the intracellular molecules and signaling pathways that control the process of morphogenesis.1

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Abelson Family Protein Tyrosine Kinases and the Formation of Neuronal Connectivity

Regulation of Cytoskeletal Dynamics and Cell Morphogenesis by Abl Family Kinases

Abelson (Abl) family nonreceptor tyrosine kinases are essential regulators of cell morphogenesis in developing metazoan organisms. Mutant animals that lack Abl kinases exhibit defects in epithelial an...

Mechanisms of Activation of Abl Family Kinases

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Abl Family Kinases in Mammalian Development

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Regulation of Cell Motility by Abl Family Kinases

Cell migration is a highly dynamic process that involves regulation of actin-mediated protrusion of a leading lamellipodia and its adhesion to the extracellular matrix, followed by translocation of th...

Chapter category: Signal Transduction

Abelson Family Protein Tyrosine Kinases and the Formation of Neuronal Connectivity

Additional chapters from this book:

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