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Chapter category: Endocrine

Insulin Action in the Islet b-Cell

This chapter appears in the following book:

Mechanisms of Insulin Action

Edited by: Alan R. Saltiel and Jeffrey E. Pessin
ISBN: 978-0-387-72203-0
» Get more information about this book at landesbioscience.com «

Chapter authors:
Rohit N. Kulkarni


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The techniques that allow spatio-temporal control of gene deletion or gene expression in transgenic and knockout animals have been useful to directly evaluate the roles of the insulin and IGF-1 receptors and proteins in their signaling pathway in islet cells. While a functional role for insulin signaling in islet b-cells is now well established, the precise pathways and proteins that mediate b-cell growth and function during development and adulthood are continuing to be unraveled. This chapter will focus on recent studies derived from using transgenic, knockout and siRNA techniques to directly examine the role of insulin and IGF-I in the regulation of development, growth and function of islet b-cells.

Rohit N. Kulkarni
Joslin Diabetes Center
and
Harvard Medical School

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Insulin Action in the Islet b-Cell

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