Chapter category: Stem Cells

Origin and Fate of Hematopoietic Precursors in the Early Mouse Embryo

This chapter appears in the following book:

Hematopoietic Stem Cell Development

Edited by: Isabelle Godin and Ana Cumano
ISBN: 0-306-47872-2
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Chapter authors:
Julien Yuan Bertrand, Alexandra Manaia, Jeanne Van Celst, Ana Cumano and Isabelle Godin

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The hematopoietic system comprises a large array of differentiated cells (lymphocytes, myeloid cells, erythrocytes, etc…) with a limited half-life. The hematopoietic com- partment thus depends on a continuous renewal throughout life. In adult mammals, mature blood cells are constantly generated in the bone marrow, from multipotent precursors endowed with self-renewal capacity: the hematopoietic stem cells (HSC), which have been considered to arise from a pool generated during ontogeny. Until recently, this model had not been tested experimentally. The existence of a lineage relationship between HSC present in the adult bone marrow and those generated during ontogeny recently receive support from experiments involving time-induced recombination event in HSC from early hematopoietic site, resulting in the activation of the gene encoding LacZ.1 The fetal liver (FL) was the first embryonic site identified as containing HSC, from 11 days post coitus (dpc) until the perinatal period.2 The FL is the major hematopoietic organ in the embryo and contributes to neonatal hematopoiesis until the two first weeks after parturition.3 At about the same stage, the thymus is already involved in the generation of T cells (from 10-11 dpc onwards). The fetal spleen, which seems to have only a minor contribution to embryonic hematopoiesis, has also been shown to contain HSC from 14 dpc until birth.4,5 The fetal bone marrow is thought to harbor HSC from 15-16 dpc.6

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Additional chapters from this book:

Origin and Fate of Hematopoietic Precursors in the Early Mouse Embryo

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Chapter category: Stem Cells

Origin and Fate of Hematopoietic Precursors in the Early Mouse Embryo

Additional chapters from this book:

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