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Chapter category: Reproductive Biology

Uterine Leiomyomata: Aspects in Reproduction, Susceptibility, and Tumor Cytogenetics

This chapter appears in the following book:

Cytogenetics in Reproductive Medicine

Edited by: Dagan Wells
ISBN: 1-58706-205-4
» Get more information about this book at landesbioscience.com «

Chapter authors:
Jennelle C. Hodge and Cynthia C. Morton


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Uterine leiomyomata (UL), commonly referred to as fibroids, are the most frequent neoplasm of the female genital tract with such high morbidity as to account annually for one-third of hysterectomies (more than 200,000 procedures), approximately 1 in 5 visits to a gynecologist, and expenditures of greater than 1.2 billion health care dollars in the U.S. Despite the major public health impact of UL, the causes of their growth and development remain largely unknown, although a variety of epidemiological, molecular and cytogenetic studies suggest a strong genetic component. The goal of this chapter is to examine the effect of UL on reproduction and to summarize the current understanding of cytogenetic aberrations and other genetic findings in UL with respect to their contributions to the pathogenesis of these tumors.

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Additional chapters from this book:

Cytogenetics of Human Preimplantation Embryos

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Uterine Leiomyomata: Aspects in Reproduction, Susceptibility, and Tumor Cytogenetics

Jennelle C. Hodge and Cynthia C. Morton

Uterine leiomyomata (UL), commonly referred to as fibroids, are the most frequent neoplasm of the female genital tract with such high morbidity as to account annually for one-third of hysterecto...

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