Chapter category: Gastroenterology
Acute Fatty Liver of Pregnancy
Maternal Liver Disease
Edited by: Jamal IbdahISBN: 1-58706-192-9
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Chapter authors:
Jerry Angdisen and Jamal A. Ibdah
Acute fatty liver of pregnancy (AFLP) is a serious maternal illness occurring in the third trimester of pregnancy with significant perinatal and maternal mortality. Till recently, it has been considered a mysterious illness. In this chapter we review the recent advances in understanding the pathogenesis of AFLP and review the studies documenting a causative association between carrying a fetus with a defect in fatty acid oxidation and development of AFLP. Further, we discuss the impact of these recent advances on the offspring born to women who develop AFLP, such that screening for a genetic defect can be life saving to the newborn and would allow genetic counseling in subsequent pregnancies. The molecular basis and underlying mechanism for this unique fetal-maternal interaction causing maternal liver disease is discussed.
Additional chapters from this book:
Acute Fatty Liver of Pregnancy
Jerry Angdisen and Jamal A. Ibdah
Acute fatty liver of pregnancy (AFLP) is a serious maternal illness occurring in the third trimester of pregnancy with significant perinatal and maternal mortality. Till recently, it has been co...
Preeclamptic Liver Disease and HELLP Syndrome
Gretchen Koontz, Jamal Ibdah, and David C. Merrill
Hypertensive disorders of pregnancy remain a devastating disease for both the mother and the fetus. Preeclampsia and HELLP syndrome, two disorders specific to pregnancy, remain a major cause o...
Intrahepatic Cholestasis of Pregnancy
Paul A. Dawson and Girish Mishra
Intrahepatic cholestasis of pregnancy (ICP), also known as obstetric cholestasis, is one of the most common causes of liver disease in pregnancy. ICP is a reversible form of cholestasis that u...
Spectrum of Maternal Liver Disease
R. Sidney G. Smith and Jamal A. Ibdah
There is a broad range of liver diseases that can occur during the course of pregnancy, including disease states which are specific to pregnancy and those which occur coincidentally with pregnancy. ...
Hyperemesis Gravidarum and Maternal Liver Disease
William M. Outlaw, Jamal A. Ibdah and Kenneth L. Koch*
Hyperemesis gravidarum (HG) is the most severe form of illness within the spectrum of nausea and vomiting of pregnancy (NVP). HG affects millions of pregnant women annually, imparts significant cost...
The Liver in Normal Pregnancy
Yannick Bacq
Changes in value of certain serum liver function tests occur during normal pregnancy and an understanding of these physiological changes is necessary for the management of liver diseases. Because of...
