Chapter category: Signal Transduction
Characteristics and Biological Functions of TRAF6
TNF Receptor Associated Factors (TRAFs)
Edited by: Hao WuISBN: 978-0-387-70629-0
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Chapter authors:
Jun-ichiro Inoue, Jin Gohda and Taishin Akiyama
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Jun-ichiro Inoue
Department of Cancer Biology, Division of Cellular and Molecular Biology, Institute of Medical Science, University of Tokyo
Jin Gohda
Department of Cancer Biology, Division of Cellular and Molecular Biology, Institute of Medical Science, University of Tokyo
Taishin Akiyama
Department of Cancer Biology, Division of Cellular and Molecular Biology, Institute of Medical Science, University of Tokyo
Additional chapters from this book:
Characteristics and Biological Functions of TRAF6
Jun-ichiro Inoue, Jin Gohda and Taishin Akiyama
TRAF6 is divergent from other members of the TRAF family. Therefore, TRAF6 was expected to play physiological roles distinct from those of other TRAFs. In this chapter, we focused on the physi...
Targeting TNF-Receptor Associated Factors (TRAFs) for Therapeutic Intervention
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TNF-Receptors Associated Factors (TRAFs) are the molecules that upon engagement of the TNF-receptor (TNFR) by a TNF-family ligand come first in contact with the activated TNFR, initially acting ...
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The lymphotoxin-b receptor (LTbR, TNFRSF3) signaling pathway activates gene transcription programs and cell death important in immune development and host defense. The TNF receptor associated fa...
Molecular Basis for the Unique Specificity of TRAF6
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Tumor necrosis factor (TNF) receptor (TNFR) associated factor 6 (TRAF6) is a unique member of the TRAF family of adaptor proteins that is involved in both the TNF receptor superfamily and the interleu...
Physiological Roles and Mechanisms of Signaling by TRAF2 and TRAF5
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TRAF2 and TRAF5 are closely related members of the TRAF family of proteins. They are important signal transducers for a wide range of TNF receptor superfamily members, including TNFR1, TNFR2, CD40 a...
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The tumor necrosis factor (TNF) receptor (TNFR) superfamily consists of over 20 type-I transmembrane proteins with conserved N-terminal cysteine-rich domains (CRDs) in the extracellular ligand bin...
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Members of the tumor necrosis factor (TNF) family govern many diverse physiological and cellular responses including cellular proliferation, differentiation, and apoptosis. Ligands of this family ...
Ubiquitination and TRAF Signaling
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The Ubiquitin-Proteasome Pathway Ubiquitin (Ub) is a highly conserved small polypeptide that is ubiquitously expressed in all eukaryotic cells. The best-known function of ubiquitin is to target pro...
TRAF1 and Its Biological Functions
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Tumor necrosis factor (TNF) receptor-associated factor (TRAF)1 was originally identified based on its ability to interact with the cytosolic domain of TNF receptor type 2 (TNFR2). TRAF1 is unique ...
Protein-Protein Interactions in TRAF3
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TNF-receptor-associated factors (TRAFs) are intracellular proteins that bind to the cytoplasmic portion of TNF receptors and mediate downstream signaling. The six known TRAF proteins play overlapping ...
TRAF Proteins in CD40 Signaling
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The tumor necrosis factor receptor (TNFR) superfamily molecule CD40 is expressed by a wide variety of cell types following activation signals, and constitutively on B lymphocytes, macrophages, and...
TRAF4, the Unique Family Member
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The fourth member of the TRAF protein family (TRAF4) presents several characteristics that distinguish it from the other members of the family. These characteristics concern the primary sequence of ...
Phylogeny of the TRAF/MATH Domain
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The TNF-Receptor Associated Factor (TRAF) domain (TD), also known as the meprin and TRAF-C homology (MATH) domain is a fold of seven anti-parallel b-helices that participates in protein-protein ...
LMP1 TRAFficking Activates Growth and Survival Pathways
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Epstein-Barr Virus (EBV) Latent Infection Membrane Protein 1 (LMP1) is expressed in all the EBV related malignancies. LMP1 expression is critical for transformation of human B-cells by EBV. LMP1...
TRAF3 and Its Biological Function
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Tumor necrosis factor receptor associated factor 3 (TRAF3) is one of the most enigmatic members in the TRAF family that consists of six members, TRAF1 to 6. Despite its similarities with other T...
