Chapter category: Oncology
p53, BRCA1 and Breast Cancer Chemoresistance
Breast Cancer Chemosensitivity
Edited by: Dihua Yu and Mien-Chie HungISBN: 978-0-387-74037-9
» Get more information about this book at landesbioscience.com «
Chapter authors:
Kimberly A. Scata and Wafik S. El-Deiry
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Kimberly A. Scata
University of Pennsylvania Medical Center
Wafik S. El-Deiry
University of Pennsylvania School of Medicine
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Novel Approaches for Chemosensitization of Breast Cancer Cells: The E1A Story
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Cell Cycle Deregulation in Breast Cancer: Insurmountable Chemoresistance or Achilles’ Heel?
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Estrogen Receptors in Resistance to Hormone Therapy
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Estrogen and its receptors a and b (ERa and ERb) play a major role in tumor progression and approximately two-thirds of breast cancers express these functional receptors. Thus, the ER is a major targe...
p53, BRCA1 and Breast Cancer Chemoresistance
Kimberly A. Scata and Wafik S. El-Deiry
The tumor suppressor genes p53 and BRCA1 are involved in hereditary as well as sporadic breast cancer development and therapeutic responses. While p53 mutations contribute to resistance to chemo- and ...
