Chapter category: Signal Transduction
Intracellular Kinases in Semaphorin Signalling
Semaphorins: Receptor and Intracellular Signaling Mechanisms
Edited by: R. Jeroen PasterkampISBN: 978-0-387-70955-0
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Chapter authors:
Originally identified as collapse-inducing and repellent proteins for neuronal processes, Semaphorins are now implicated in a diverse array of cellular responses, contributing not only to embryonic development, but also to the maintenance of tissue integrity in the adult organism. In addition, Semaphorins play a role in the pathological context. Some Semaphorins can act at a distance, facilitating the navigation of cells or axonal process, whilst others evoke responses in a contact-dependent fashion. The intracellular signalling mechanisms employed by the Semaphorins are beginning to be determined, and much work in recent years implicates a host of intracellular kinases in mediating Semaphorin function. These include the tyrosine kinase Fyn and the serine/threonine kinases Cdk5, GSK3, MAPK, and LIMK, and the lipid kinase PI3K. What follows is a review of this work with respect to their functions in mediating specific Semaphorin-induced responses.
Additional chapters from this book:
Signaling of Secreted Semaphorins in Growth Cone Steering
Secreted semaphorins [class 3 semaphorins (3A-3F) in vertebrates and class 2 in inverte- brates] play essential roles in the establishment of neuronal circuitry by mediating axon steering and fascicul...
Proteoglycans as Modulators of Axon Guidance Cue Function
Organizing a functional neuronal network requires the precise wiring of neuronal connections. In order to find their correct targets, growth cones navigate through the extracellular matrix guided by s...
Semaphorin Signaling in Vascular and Tumor Biology
The neuropilins were originally characterized as cell membrane receptors that bind axon guidance factors belonging to the class-3 semaphorin subfamily. To transduce semaphorin signals, they form compl...
Semaphorin Signals in Cell Adhesion and Cell Migration: Functional Role and Molecular Mechanisms
Cell migration is pivotal in embryo development and in the adult. During development, a wide range of progenitor cells travel over long distances before undergoing terminal differentiation. Moreover, ...
GTPases in Semaphorin Signalling
A hallmark of semaphorin receptors is their interaction with multiple GTPases. Plexins, the signal transducing component of semaphorin receptors, directly associate with several GTPases. In addition, ...
Semaphorin Signaling during Cardiac Development
A number of semaphorins have been shown to play crucial roles as axon guidance cues in the wiring of the nervous system, including axon fasciculation, branching, and target selection. However, increas...
Intracellular Kinases in Semaphorin Signalling
Originally identified as collapse-inducing and repellent proteins for neuronal processes, Semaphorins are now implicated in a diverse array of cellular responses, contributing not only to embryonic de...
Modulation of Semaphorin Signaling by Ig Super Family Cell Adhesion Molecules
During axon navigation, growth cones continuously interact with molecular cues in their environment, some of which control adherence and bundle assembly, others axon elongation and direction. Growth c...
MICAL Flavoprotein Monooxygenases: Structure, Function and Role in Semaphorin Signaling
MICALs (for Molecule Interacting with CasL) form a recently discovered family of evolutionary conserved signal transduction proteins. They contain multiple well-conserved domains known for interaction...
The CRMP Family of Proteins and Their Role in Sema3A Signaling
The CRMP proteins were originally identified as mediators of Sema3A signaling and neuronal differentiation. Much has been learned about the mechanism by which CRMPs regulate cellular responses to Sema...
