Chapter category: Cell Metabolism
Beyond the Lipid Hypothesis: Mechanisms Underlying Phenotypic Plasticity in Inducible Cold Tolerance
Molecular Aspects of the Stress Response: Chaperones,
Membranes and Networks
Edited by: Peter Csermely and László VíghISBN: 0-387-39974-7
» Get more information about this book at landesbioscience.com «
Chapter authors:
Scott A.L. Hayward, Patricia A. Murray, Andrew Y. Gracey and Andrew Cossins
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Scott A.L. Hayward
School of Biological Sciences, Liverpool University
Patricia A. Murray
School of Biological Sciences, Liverpool University
Andrew Y. Gracey
School of Biological Sciences, Liverpool University
Andrew Cossins
School of Biological Sciences, Liverpool University
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Protein Misassembly: Macromolecular Crowding and Molecular Chaperones
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The generic tendency of proteins to misassemble into nonfunctional, and sometimes cytotoxic, structures poses a universal problem for all types of cell. This problem is exacerbated by the high total...
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Hsp90 is an essential and ubiquitous molecular chaperone that is required for the proper folding of a set of client proteins at a late stage in their folding process. In eukaryotes, cytoplasmic Hsp9...
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Heat Shock Factor 1 As a Coordinator of Stress and Developmental Pathways
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The transition from normal growth conditions to stressful conditions is accompanied by a robust upregulation of heat shock proteins, which dampen the cytotoxicity caused by misfolded and denatured p...
Chaperones as Parts of Cellular Networks
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The most important interactions between cellular molecules have a high affinity, are unique and specific, and require a network approach for a detailed description. Molecular chaperones usually have...
Organization of the Functions and Components of the Endoplasmic Reticulum
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The endoplasmic reticulum is the site of entry into the secretory pathway and represents a major and particularly crowded site of protein biosynthesis. In addition to the complexity of protein foldi...
Mechanisms of Activation and Regulation of the Heat Shock-Sensitive Signaling Pathways
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Heat shock (HS), like many other stresses, induces specific and highly regulated signaling cascades that promote cellular homeostasis. The three major mitogen-activated protein kinases (MAPK) and pr...
Chaperone Regulation of the Heat Shock Protein Response
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The heat shock protein response appears to be triggered primarily by nonnative proteins accumulating in a stressed cell and results in increased expression of heat shock proteins (HSPs). Many heat s...
Membrane-Regulated Stress Response: A Theoretical and Practical Approach
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A number of observations have lent support to a model in which thermal stress is trans- duced into a signal at the level of the cellular membranes. Our alternative, but not exclusive, approach is...
Beyond the Lipid Hypothesis: Mechanisms Underlying Phenotypic Plasticity in Inducible Cold Tolerance
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The physiological adjustment of organisms in response to temperature variation is a crucial part of coping with environmental stress. An important component of the cold response is the increase in m...
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A growing number of human neurodegenerative diseases are associated with the expression of misfolded proteins that oligomerize and form aggregate structures. Over time, accumulation of misfolded pro...
