Chapter category: Gene Expression
Evolutionary Genomics of Hox Gene Clusters
HOX Gene Expression
Edited by: Spyros PapageorgiouISBN: 978-0-387-68989-0
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Additional chapters from this book:
Homeobox-Containing Genes in Limb Regeneration
Early investigations established an important role for homeobox-containing genes in the initiation of regeneration, as well as in the later pattern formation events leading to a new limb. The recent i...
HOX Genes and Stem Cells
Stem cells are cells that undergo self-renewal as well as differentiation into progenitor cells. They are abundantly present, although ill defined, during development and it is believed that most, if ...
Evolution of Hox Gene Clusters
The Hox gene clusters have been one of the most prominent paradigms within Developmental Biology. This stems from the great excitement that surrounded the discovery that the genes all contained the co...
Deregulation of the HOX Gene Network and Cancer
Although the Hox genes have been identified as master regulatory genes controlling embryonic development, an alternative view on the role of the Hox gene network suggests that it regulates crucial pro...
The Hox Gene Network in Vertebrate Limb Development
The Hox gene network has multiple roles in vertebrate limb development. One of its main functions is to encode positional information thus providing a “Hox” code for the pattern of structures along th...
Expression of Hox Genes in the Nervous System of Vertebrates
The vertebrate nervous system is a major site of Hox gene expression and function. Studies on the patterns of expression, regulation and function of the vertebrate Hox gene family have played a key ro...
Hypothesis: Pulling Forces Acting on Hox Gene Clusters Cause Expression Collinearitya
The development of normal patterns along the primary and secondary vertebrate axes depends on the regularity of early Hox gene expression. During initial stages, these expression events form a sequent...
The Homeobox as a Key for Understanding the Principles of the Genetic Control of Development
The discovery of the homeobox, and the Hox gene clusters have uncovered a general universal principle of the genetic control of development. In all bilaterian animals these Hox clusters determine the ...
Evolutionary Genomics of Hox Gene Clusters
The evolution of Hox clusters in vertebrates follows different patterns than those of in-vertebrate clusters. More stringent structural constraints in vertebrates are apparent from tighter cluster org...
Chromatin and the Control of Hox Gene Expression
Antero-posterior patterning of the animal embryo is governed in part by the highly conserved Hox genes. In most animals studied to date, Hox genes are assembled within one or more clusters. The thirty...
