Chapter category: Adhesion Molecules
Akt and Pancreatic b-Cell Growth and Function
Islet Cell Growth Factors
Edited by: Rohit N. KulkarniISBN: TBA
» Get more information about this book at landesbioscience.com «
Chapter authors:
Ernesto Bernal-Mizrachi
The serine-threonine kinase Akt also known as protein kinase B is one of the most studied molecules. In addition to the important role in carcinogenesis, Akt is a major regulator of carbohydrate metabolism. Akt mediates insulin-dependent glucose uptake in insulin-sensitive tissues. Recent evidence underscores the importance of Akt for regulation of b-cell mass and function. This review summarizes current findings concerning the molecular mechanisms, downstream signaling pathways and critical components involved in regulation of b-cell growth and function by Akt. The results of these observations suggest that elucidation of critical downstream effectors of this signaling pathway could generate promising molecules as a potential targets to induce proliferation and survival of b-cells.
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