Chapter category: Endocrine
Relaxin Physiology in the Female Reproductive Tract during Pregnancy
Relaxin and Related Peptides
Edited by: Alexander I. AgoulnikISBN: 978-0-387-74670-8
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Chapter authors:
Laura J. Parry and Lenka A. Vodstrcil
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Laura J. Parry
Department of Zoology, University of Melbourne
Lenka A. Vodstrcil
Department of Zoology, University of Melbourne
Additional chapters from this book:
Relaxin, the Relaxin-Like Factor and Their Receptors
Christian Schwabe and Erika E. Büllesbach
In 1926 Frederick Hisaw discovered a blood‑borne factor in pregnant guinea pigs that would cause relaxation of the pubic symphysis in virgin females of the species.1The relaxin‑like factor...
Relaxin-Family Peptide and Receptor Systems in Brain Insights from Recent Anatomical and Functional Studies
Sherie Ma and Andrew L. Gundlach
Relaxin was for many years considered primarily a hormone active within the reproductive tract with overwhelming evidence for its important roles in mammalian parturition. More\\r\\n R...
The Effects of Relaxin on Extracellular Matrix Remodeling in Health and Fibrotic Disease
Chrishan S. Samuel, Edna D. Lekgabe and Ishanee Mookerjee
Since its discovery as a reproductive hormone 80 years ago, relaxin has been implicated in a number of pregnancy‑related functions involving extracellular matrix (ECM) turnover and collagen degr...
Diverse Signalling Mechanisms Used by Relaxin in Natural Cells and Tissues: The Evolution of a “Neohormone”
Richard Ivell, Kee Heng and Ravinder Anand-Ivell
The small peptide hormone relaxin is a member of a rapidly evolving family of hormones and growth factors, whose mode of action appears to be particularly adapted to purely mammalian physiology. It is...
Relaxin and Related Peptides in Male Reproduction
Alexander I. Agoulnik
The relaxin hormone is renowned for its function in pregnancy, parturition and other aspects of female reproduction. At the same time, the role of relaxin in male reproduction is still debated. Relaxi...
The Evolution of the Relaxin Peptide Family and Their Receptors
Tracey N. Wilkinson and Ross A.D. Bathgate
The relaxin peptide family in humans consists of relaxin‑1, 2 and 3 and the insulin‑like peptides (INSL)‑3, 4, 5 and 6. The evolution of this family has been controversial; points of...
Relaxin Physiology in the Female Reproductive Tract during Pregnancy
Laura J. Parry and Lenka A. Vodstrcil
The characteristic functions of relaxin are associated with female reproductive tract physiology. These include the regulation of biochemical processes involved in remodeling the extracellular matrix ...
The Vascular Actions of Relaxin
Arundhathi Jeyabalan, Sanjeev G. Shroff, Jaqueline Novak and Kirk P. Conrad
Relaxin is emerging as a hormone with important vascular actions. Much of our recently gained knowledge of relaxin in this context has stemmed from investigations of maternal vascular adaptations to p...
Relaxin-Like Ligand-Receptor Systems Are Autocrine/Paracrine Effectors in Tumor Cells and Modulate Cancer Progression and Tissue Invasiveness
Thomas Klonisch, Joanna Bialek, Yvonne Radestock, Cuong Hoang-Vu and Sabine Hombach-Klonisch
Relaxin and INSL3 are novel autocrine/paracrine insulin‑like hormones in tumor biology. Both effectors can bind to and activate the leucine‑rich G‑protein coupled receptors LGR7 (rel...
