Chapter category: RNA
Alternative Splicing in Disease
Alternative Splicing
in the Postgenomic Era
Edited by: Benjamin J. Blencowe and Brenton R. GraveleyISBN: 978-0-387-77373-5
» Get more information about this book at landesbioscience.com «
Chapter authors:
James P. Orengo and Thomas A. Cooper
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James P. Orengo
Departments of Pathology and Molecular
and Cellular Biology, Baylor College of Medicine
Thomas A. Cooper
Departments of Pathology and Molecular
and Cellular Biology, Baylor College of Medicine
Additional chapters from this book:
Coupling Transcription and Alternative Splicing
Alberto R. Kornblihtt
Alternative splicing regulation not only depends on the interaction of splicing factors with splicing enhancers and silencers in the pre‑mRNA, but also on the coupling between transcription and ...
Searching for Splicing Motifs
Lawrence A. Chasin
Intron removal during pre‑mRNA splicing in higher eukaryotes requires the accurate identification of the two splice sites at the ends of the exons, or exon definition. The sequences constituting...
Nuclear Organization and Splicing Control
Maria Carmo-Fonseca and Célia Carvalho
Although major splicing regulatory mechanisms rely on the presence of cis‑acting sequence elements in the precursor messenger RNA (pre‑mRNA) to which specific protein and RNA factors bind,...
Alternative Splicing in Disease
James P. Orengo and Thomas A. Cooper
Alternative splicing is a major source of diversity in the human proteome. The regulation of alternative splicing modulates the composition of this diversity to fulfill the physiological requirements ...
SR Proteins and Related Factors in Alternative Splicing
Shengrong Lin and Xiang-Dong Fu
SR proteins are a family of RNA binding proteins that contain a signature RS domain enriched with serine/arginine repeats. The RS domain is also found in many other proteins, which are collectively re...
Regulation of Alternative Splicing by Signal Transduction Pathways
Kristen W. Lynch
Alternative splicing is now recognized as a ubiquitous mechanism for controlling gene expression in a tissue‑specific manner. A growing body of work from the past few years has begun to also hig...
Relating Alternative Splicing to Proteome Complexity and Genome Evolution
Yi Xing and Christopher Lee
Prior to genomics, studies of alternative splicing primarily focused on the function and mechanism of alternative splicing in individual genes and exons. This has changed dramatically since the late 1...
hnRNP Proteins and Splicing Control
Rebeca Martinez-Contreras, Philippe Cloutier, Lulzim Shkreta, Jean‑François Fisette, Timothée Revil and Benoit Chabot
Proteins of the heterogeneous nuclear ribonucleoparticles (hnRNP) family form a structurally diverse group of RNA binding proteins implicated in various functions in metazoans. Here we discuss recent ...
Complex Alternative Splicing
Jung Woo Park and Brenton R. Graveley
Alternative splicing is a powerful means of controlling gene expression and increasing protein diversity. Most genes express a limited number of mRNA isoforms, but there are several examples of genes ...
Technologies for the Global Discovery and Analysis of Alternative Splicing
John A. Calarco, Arneet L. Saltzman, Joanna Y. Ip and Benjamin J. Blencowe
During the past ~20 years, studies on alternative splicing (AS) have largely been directed at the identification and characterization of factors and mechanisms responsible for the control of splice si...
Functional and Mechanistic Insights From Genome‑Wide Studies of Splicing Regulation in the Brain
Jernej Ule and Robert B. Darnell
We review here results arising from the systematic functional analysis of Nova, a neuron‑specific RNA binding protein targeted in an autoimmune neurological disorder associated with cancer. We h...
Spliceosome Assembly and Composition
Arianne J. Matlin and Melissa J. Moore
Cells control alternative splicing by modulating assembly of the pre‑mRNA splicing machinery at competing splice sites. Therefore, a working knowledge of spliceosome assembly is essential for un...
The Coupling of Alternative Splicing and Nonsense‑Mediated mRNA Decay
Liana F. Lareau, Angela N. Brooks, David A.W. Soergel, Qi Meng and Steven E. Brenner
Most human genes exhibit alternative splicing, but not all alternatively spliced transcripts produce functional proteins. Computational and experimental results indicate that a substantial fraction of...
