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Chapter category: DNA

Schistosome DNA Transposons

This chapter appears in the following book:

Mobile Genetic Elements in Metazoan Parasites

Edited by: Paul J. Brindley
ISBN: 978-1-58706-093-9
» Get more information about this book at landesbioscience.com «

Chapter authors:
Ricardo DeMarco and Sergio Verjovski-Almeida


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Schistosomes are digenetic blood flukes and the causative agents of schistosomiasis in humans. Large transcriptome and genome sequence databases have recently become publicly available for Schistosoma mansoni and S. japonicum and have provided a comprehensive repository for the discovery of novel repetitive elements. In fact, two DNA transposons, namely Merlin_Sm1 and SmTRC1, have been recently described in S. mansoni and are the first classical transposons to be described in platyhelminths. This chapter reviews the characterization of each of these elements in relation to structure, transcription and putative encoded proteins, and provides a critical analysis on the potential use of these two elements as tools for transgenesis and mutagenesis of schistosomes.

Ricardo DeMarco
Universidade de Sao Paulo

Sergio Verjovski-Almeida

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Schistosome DNA Transposons

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