Chapter category: Endocrine
Aromatase Expression in Women’s Cancers
Innovative Endocrinology of Cancer
Edited by: Lev M. Berstein and Richard J. SantenISBN: 978-0-387-78817-3
» Get more information about this book at landesbioscience.com «
Chapter authors:
Serdar E. Bulun and Evan R. Simpson
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Serdar E. Bulun
Department of Obstetric and Gynecology, Northwestern University, Chicago, Illinois USA
Evan R. Simpson
Prince Henry's Institute of Medical Research
Additional chapters from this book:
Breast Development, Hormones and Cancer
Jose Russo and Irma Russo
Breast cancer originates in undifferentiated terminal structures of the mammary gland. The terminal ducts of the Lob 1 of the human female breast, which are the sites of origin of ductal carcinomas, a...
Role of Endocrine-Genotoxic Switchings in Cancer and Other Human Diseases: Basic Triad
Lev M. Berstein
Cancer is one of the leading causes of human death and belongs to the group of main chronic noncommunicable diseases (NCD). Certain specific features of NCD have raised the concept of ‘normal’ and ‘su...
Progesterone Receptor Action: Translating Studies in Breast Cancer Models to Clinical Insights
Carol A. Lange, Carol A. Sartorius , extra--please delete , Monique A. Spillman, Kathryn B. Horwitz and Britta M. Jacobsen
Progesterone receptors (PR) are useful prognostic indicators of breast cancers likely to respond to anti‑estrogen receptor (ER) therapies. However, the role of progesterone, therapeutic progesti...
Epidemiology of Hormone‑Associated Cancers as a Reflection of Age
Svetlana V. Ukraintseva, Konstantin G. Arbeev and Anatoli I. Yashin
In this chapter we review the epidemiology of hormone‑associated cancers (prostate, breast, endometrial, ovarian, pancreatic and thyroid) paying special attention to the variability in the age p...
Selective Estrogen Modulators as an Anticancer Tool: Mechanisms of Efficiency and Resistance
Surojeet Sengupta and V. Craig Jordan
The majority of breast cancers are estrogen receptor (ER) positive and depend on estrogen for growth. Therefore, blocking estrogen mediated actions remains the strategy of choice for the treatment and...
Mechanisms of Hormone Carcinogenesis: Evolution of Views, Role of Mitochondria
Jin-Qiang Chen, Terry R. Brown and James D. Yager
Cumulative and excessive exposure to estrogens is associated with increased breast cancer risk. The traditional mechanism explaining this association is that estrogens affect the rate of cell division...
Obesity and Diabetes Epidemics: Cancer Repercussions
Anette Hjartåker, Hilde Langseth and Elisabete Weiderpass
The prevalence of overweight (body mass index, BMI, between 25 and 30 kg/m2) and obesity (BMI of 30 kg/m2 or higher) is increasing rapidly worldwide, especially in developing countries and countries u...
Cell Cycle Machinery: Links with Genesis and Treatment of Breast Cancer
Alison J. Butt, C. Elizabeth Caldon, Catriona M. McNeil, Alexander Swarbrick, Elizabeth A. Musgrove and Robert L. Sutherland
Loss of normal growth control is a hallmark of cancer. Thus, understanding the mechanisms of tissue‑specific, normal growth regulation and the changes that occur during tumorigenesis may provide...
Endogenous Hormone Levels and Risk of Breast, Endometrial and Ovarian Cancer: Prospective Studies
A. Heather Eliassen and Susan E. Hankinson
Multiple lines of evidence support a central role of hormones in the etiology of breast, endometrial and ovarian cancers. Evidence of an association between circulating hormones and these cancers vari...
Proteomics of Cancer of Hormone-Dependent Tissues
Darren R. Tyson and David K. Ornstein
Serum and tissue biomarkers have begun to play an increasingly important role in the detection and management of many cancers of hormone‑sensitive tissues. Specifically, the introduction of seru...
Aromatase Expression in Women’s Cancers
Serdar E. Bulun and Evan R. Simpson
Estrogen has been positively linked to the pathogenesis and growth of three common women’s cancers (breast, endometrium and ovary). A single gene encodes the key enzyme for estrogen biosynthesis named...
Prevention of Breast Cancer Using SERMs
Trevor J. Powles
The development of breast cancer is dependant in part on oestrogen. Suppression of ovarian function or use of anti‑oestrogens will reduce the incidence of breast cancer. Many trials have now bee...
Hormonal Heterogeneity of Endometrial Cancer
Carsten Gründker, Andreas R. Günthert and Günter Emons
Endometrial cancer is the most common malignant tumor of the female genital tract in the developed world. Increasing evidence suggests that the majority of cases can be divided into two different type...
Pharmacogenomics of Endocrine Therapy in Breast Cancer
Richard Weinshilboum
The treatment of breast cancer with selective estrogen receptor modulators such as tamoxifen and with aromatase inhibitors represents a major advance in cancer chemotherapy. However, there are large v...
Adaptation to Estradiol Deprivation Causes Up‑Regulation of Growth Factor Pathways and Hypersensitivity to Estradiol in Breast Cancer Cells
Richard J. Santen, Robert X. Song, Shigeru Masamura, Wei Yue, Ping Fan, Tetsuya Sogon, Shin-ichi Hayashi, Kei Nakachi and Hidtek Eguchi
Deprivation of estrogen causes breast tumors in women to adapt and develop enhanced sensitivity to this steroid. Accordingly, women relapsing after treatment with oophorectomy, which substantially low...
