Chapter category:
Promiscuous Drugs from Pathogenic Bacteria in the Post-Antibiotics Era
Patho-Biotechnology
Edited by: Roy Sleator and Colin HillISBN: 978-1-58706-304-6
» Get more information about this book at landesbioscience.com «
Chapter authors:
Arsenio M. Fialho, Tapas K. Das Gupta and Ananda M. Chakrabarty
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Arsenio M. Fialho
Tapas K. Das Gupta
Ananda M. Chakrabarty
Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, Illinois, USA
Additional chapters from this book:
Promiscuous Drugs from Pathogenic Bacteria in the Post-Antibiotics Era
Arsenio M. Fialho, Tapas K. Das Gupta and Ananda M. Chakrabarty
The era of the antibiotics, active against prokaryotic and lower eukaryotic infectious agents, is believed to be coming to an end, because of the rapid development of antibiotic resistance in suscepti...
Application of Bacterial Pathogens in Replacement Therapy
John R. Tagg, Jeremy P. Burton and Philip A. Wescombe
As our knowledge of the cellular content and intercellular dynamics of the indigenous microbiota increases, so too does our ability to rationally adjust its composition to heighten its specific pathog...
Attack and Counter‑Attack: Targeted Immunomodulation Using Bacterial Virulence Factors
Mohammed Bahey-El-Din, Brendan T. Griffin and Cormac G.M. Gahan
Virulence factors of pathogenic bacteria by definition play a crucial role in infectivity and pathogenesis. Many of these factors have evolved to modulate the host immune response often in a manner th...
Phage therapy: A Trojan Horse Approach to the Control of Intracellular Pathogens
Lawrence Broxmeyer
If Biotechnology describes the exploitation of living systems or their products towards biomedical processes, then few entities have a greater biotechnological potential than the use of bacteriophages...
The Use of Recombinant Phage Lysins for the Control of Bacterial Pathogens
Marianne Horgan, Aidan Coffey, R. Paul Ross, Jim O'Mahony, Gerald F. Fitzgerald and Olivia McAuliffe
Endolysins are bacteriophage‑encoded peptidoglycan hydrolases that accumulate in the cytosol of phage‑infected bacterial cells, resulting in eventual cell lysis at the end of the lytic cyc...
In Vivo Remote Control of Bacterial Vectors for Prophylaxis and Therapy
Holger Loessner and Siegfried Weiss
The use of live attenuated bacteria as prophylactic vaccines has a proven track record in human and veterinary medical praxis. In addition, bacteria‑based medicines are currently developed for t...
Cosmetic and Therapeutic Applications of Botulinum Toxin in the Head and Neck
Nwanmegha Young and Andrew Blitzer
Botulinum toxin is the most potent neurotoxin known to man. It is produced by the anaerobic bacteria Clostridium botulinum . In the early nineteenth century, it was responsible for large outbreaks of ...
Viral Pathogens as Therapeutic Delivery Vehicles
Helen O'Shea
The term patho‑biotechnology describes the exploitation of pathogenic bacteria for beneficial applications in food and biomedicine. We propose extending this definition to include viruses, for s...
Bacterial Vectors for RNAi Delivery
Thu Nguyen and Johannes H. Fruehauf
RNA interference (RNAi) is a recently discovered powerful research tool which allows the targeted “silencing” of particular genes. RNAi is also thought to have immense therapeutic potential to treat a...
Bacteria Mediated Gene Therapy Strategies
Sophie Conchon and Georges Vassaux
The recent discovery that genes carried by bacterial vectors can be functionally transferred to mammalian cells has led to the utilization of various bacterial strains in gene therapy. Genetically mod...
Genetic Immunization: Bacteria as DNA Vaccine Delivery Vehicles
Pablo Daniel Becker, Miriam Noerder and Carlos Alberto Guzmán
The so‑called DNA vaccination represents one of the most notable tools under development in the field of vaccinology. The concept of administering the gene coding for any given protective antige...
Use of Intracellular Bacteria for the Development of Tools for Tumor Therapy and the Detection of Novel Antibacterial Targets
Christoph Schoen, Jochen Stritzker, Thilo M. Fuchs, Stephanie Weibel, Ivaylo Gentschev, Aladar A. Szalay and Werner Goebel
Intracellularly replicating bacteria are suitable tools for a combined immunological and drug therapy of tumors. For example, virulence‑attenuated strains of L. monocytogenes, Salmonella spp., S...
Engineered Pharmabiotics with Improved Therapeutic Potential
Roy Sleator and Colin Hill
Although described for over a century, scientists and clinicians alike are only now beginning to realise the significant medical applications of probiotic cultures. Given the increasing commercial and...
Improvement of Insect Pathogens as Insecticides through Genetic Engineering
Brian A. Federici, Bryony C. Bonning and Raymond J. St Leger
Viruses and microorganisms that cause disease in insects have been under evaluation as insecticides for more than a century. Only Bacillus thuringiensis (Bt) has been a commercial success and even so ...
Bacterial ghosts as vaccine and drug delivery platforms
Ulrike Beate Mayr, Verena Juliana Koller, Petra Lubitz and Werner Lubitz
The Bacterial Ghost (BG) Vaccine Platform Technology represents a particulate carrier system for protein subunit or DNA‑encoded antigens endowed with intrinsic adjuvant properties. By all its bi...
