Chapter category:
Dynamic Regulation of Antigen Receptor Gene Assembly
V(D)J Recombination
Edited by: Pierre FerrierISBN: TBA
» Get more information about this book at landesbioscience.com «
Chapter authors:
Lance R. Thomas, Robin Milley Cobb and Eugene M. Oltz
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Lance R. Thomas
Robin Milley Cobb
Eugene M. Oltz
Department of Microbiology and Immunology, Vanderbilt University
Additional chapters from this book:
Germline Transcription: A Key Regulator of Accessibility and Recombination
Iratxe Abarrategui and Michael S. Krangel
The developmental control of V(D)J recombination is imposed at the level of chromatin accessibility of recombination signal sequences (RSSs) to the recombinase machinery. Cis‑acting transcriptio...
Dynamic Regulation of Antigen Receptor Gene Assembly
Lance R. Thomas, Robin Milley Cobb and Eugene M. Oltz
A hallmark feature of adaptive immunity is the production of lymphocytes bearing an enormous repertoire of receptors for foreign antigens. This repertoire is generated early in B and T‑cell deve...
V(D)J Recombination Deficiencies
Jean-Pierre de Villartay
V(D)J recombination not only comprises the molecular mechanism that insures diversity of the immune system but also constitutes a critical checkpoint in the developmental program of B‑ and TR...
Regulation of V(D)J recombination by E‑protein transcription factors
Mary Elizabeth Jones and Yuan Zhuang
Extensive study of the E‑proteins E2A and HEB during lymphocyte development has revealed various functions for these bHLH transcription factors in regulating V(D)J recombination in both B- and T...
Genetic and Epigenetic Control of V Gene Rearrangement Frequency
Ann J. Feeney
The antibody repertoire is enormous and reflects the power of combinatorial and junctional diversity to generate a vast repertoire with a moderate number of V, D and J gene segments. However, although...
Molecular Genetics at the T‑Cell Receptor β Locus:
Insights into the Regulation of V(D)J Recombination
Marie Bonnet, Pierre Ferrier and Salvatore Spicuglia
The V(D)J recombination machinery assembles antigen receptor genes from germline V, D and J segments during lymphocyte development. In αβT cells, this leads to the production of the T‑...
Large‑Scale Chromatin Remodeling at the Immunoglobulin Heavy Chain Locus—A Paradigm for Multigene Regulation
Daniel J. Bolland, Andrew L. Wood and Anne E. Corcoran
V(D)J recombination in lymphocytes is the cutting and pasting together of antigen receptor genes in cis to generate the enormous variety of coding sequences required to produce diverse antigen recepto...
Regulation of RAG Transposition
Adam G.W. Matthews and Marjorie A. Oettinger
V(D)J recombination is initiated by the lymphoid specific proteins RAG1 and RAG2, which together constitute the V(D)J recombinase. However, the RAG1/2 complex can also act as a transposase, inserting ...
Normal and Pathological VDJ Recombination: Contribution to the Understanding of Human Lymphoid Malignancies
Saïda Dadi, Sandrine Le Noir, Vahid Asnafi, Kheïra Beldjord and Elizabeth A. Macintyre
The majority of haematological cancers involve the lymphoid system. They include acute lymphoblastic leukemias (ALL), which are arrested at variable stages of development and present with blood and bo...
Dynamic aspects of TCRα gene recombination: Qualitative and Quantitative Assessments of the TCRα Chain Repertoire in Man and Mouse
Evelyne Jouvin-Marche, Patrizia Fuschiotti and Patrice Noël Marche
Most T‑lymphocytes express a highly specific antigen receptor (TCR) on their cell surface, consisting of a clonotypic αβ‑heterodimer. Both α‑ and β chains are pro...
Recent Insights into the Formation of RAG‑Induced Chromosomal Translocations
Vicky L. Brandt and David B. Roth
Chromosomal translocations are found in many types of tumors, where they may be either a cause or a result of malignant transformation. In lymphoid neoplasms, however, it is clear that pathogenesis is...
Molecular Pathways and Mechanisms Regulating the Recombination of Immunoglobulin Genes During B-Lymphocyte Development
Kristen Johnson, Karen L. Reddy and Harinder Singh
The hallmark of B‑cell development is the ordered recombination of immunoglobulin (Ig) genes. Recently, considerable progress has been achieved in assembling gene regulatory networks comprised o...
Early Steps of V(D)J Rearrangement: Insights from Biochemical Studies of RAG-RSS Complexes
Patrick C. Swanson, Sushil Kumar and Prafulla Raval
V(D)J recombination is initiated by the synapsis and cleavage of a complementary (12/23) pair of recombination signal sequences (RSSs) by the RAG1 and RAG2 proteins. Our understanding of these process...
