Chapter category: Signal Transduction
Inhibitors Targeting Two‑Component Signal Transduction
Bacterial Signal Transduction:
Networks and Drug Targets
Edited by: Ryutaro UtsumiISBN: 978-0-387-78884-5
» Get more information about this book at landesbioscience.com «
Chapter authors:
Takafumi Watanabe, Ario Okada, Yasuhiro Gotoh and Ryutaro Utsumi
[+] view image
Takafumi Watanabe
Department of Bioscience, Graduate School
of Agriculture, Kinki University
Ario Okada
Department of Bioscience, Graduate School
of Agriculture, Kinki University
Yasuhiro Gotoh
Department of Bioscience, Graduate School
of Agriculture, Kinki University
Ryutaro Utsumi
Department of Bioscience, Graduate School of Agriculture, Kinki University
Additional chapters from this book:
Vancomycin Resistance VanS/VanR Two‑Component Systems
Hee-Jeon Hong, Matthew I. Hutchings and Mark J. Buttner
Vancomycin is a member of the glycopeptide class of antibiotics. Vancomycin resistance (van) gene clusters are found in human pathogens such as Enterococcus faecalis, Enterococcus faecium and Staphylo...
The Roles of Two-Component Systems in Virulence of Pathogenic Escherichia coli and Shigella spp.
Toru Tobe
Two‑component systems (TCSs) are well conserved among E. coli strains, including pathogenic E. coli and also closely related Shigella spp. Although 25% of the genome of pathogenic E. coli is str...
RegB/RegA, A Global Redox-Responding Two-Component System
Jiang Wu and Carl E. Bauer
The RegB‑RegA regulon from Rhodobacter capsulatus and Rhodobacter sphaeroides encodes proteins involved in numerous energy‑generating and energy‑utilizing processes such as photosynt...
The BvgS/BvgA Phosphorelay System of Pathogenic Bordetellae: Structure, Function and Evolution
Dagmar Beier and Roy Gross
In the genus Bordetella several important human and animal pathogens are classified with B. pertussis, the etiological agent of whooping cough, being medically the most relevant. In these bacteria exp...
Small RNAs Controlled by Two‑Component Systems
Claudio Valverde and Dieter Haas
Two‑component systems (TCSs) allow bacteria to monitor diverse environmental cues and to adjust gene expression accordingly at the transcriptional level. It has been recently recognized that pro...
Dual Regulation with Ser/Thr Kinase Cascade and a His/Asp TCS in Myxococcus xanthus
Sumiko Inouye and Hirofumi Nariya
Fruiting body development of Myxococcus xanthus is propelled by temporal gene expression directed via stage‑specific intercellular signaling pathways. M. xanthus exhibits social behaviors during...
Structural Basis of the Signal Transduction in the Two‑Component System
Seiji Yamada and Yoshitsugu Shiro
Two‑component system (TCS) consists of two multi‑domain proteins, a sensor histidine kinase (HK) and a response regulator (RR). In response to environmental change, the signal is transduce...
Two-Component Signaling Systems and Cell Cycle Control in Caulobacter crescentus
Erin B. Purcell, Cara C. Boutte and Sean Crosson
Recent work on the regulation of prokaryotic growth and development by two‑component systems (TCS) has revealed unsuspected levels of complexity. In the dimorphic freshwater bacterium Caulobacte...
Two‑Component Signaling and Gram Negative Envelope Stress Response Systems
Dawn M. MacRitchie, Daelynn R. Buelow, Nancy L. Price and Tracy L. Raivio
Bacteria have evolved complex stress responses that allow them to respond to their surroundings. In Gram negative bacteria, these stress responses can be compartmentalized into the cytoplasmic and ext...
The Two-Component Network and the General Stress Sigma Factor RpoS (σS) in Escherichia coli
Regine Hengge
The general stress sigma factor RpoS (σS) is induced during entry into stationary phase and in response to multiple stress conditions. RpoS is regulated at the levels of transcription, translatio...
Capturing the VirA/VirG TCS of Agrobacterium tumefaciens
Yi-Han Lin, Rong Gao, Andrew N. Binns and David G. Lynn
Two‑component systems (TCS) regulate pathogenic commitment in many interactions and provide an opportunity for unique therapeutic intervention. The VirA/VirG TCS of Agrobacterium tumefaciens med...
Q uorum Sensing and Biofilm Formation by Streptococcus mutans
Dilani Senadheera and Dennis G. Cvitkovitch
Streptococcus mutans is the primary causative agent involved in dental caries in humans. Among important virulence factors of this pathogen, its ability to form and sustain a polysaccharide‑enca...
Introduction to Bacterial Signal Transduction Networks
Yoko Eguchi and Ryutaro Utsumi
Transcriptional analysis using a DNA microarray is an extremely efficient method for analyzing two‑component signal transduction networks. Here we introduce three such networks in Escherichia co...
Inhibitors Targeting Two‑Component Signal Transduction
Takafumi Watanabe, Ario Okada, Yasuhiro Gotoh and Ryutaro Utsumi
A two‑component signal transduction system (TCS) is an attractive target for antibacterial agents. In this chapter, we review the TCS inhibitors developed during the past decade and introduce no...
The PhoQ/PhoP Regulatory Network of Salmonella enterica
Akinori Kato and Eduardo A. Groisman
The PhoQ/PhoP two‑component regulatory system is a major regulator of virulence in the enteric pathogen Salmonella enterica serovar Typhimurium. It also controls the adaptation to low Mg2+ envir...
Tearing Down the Wall: Peptidoglycan Metabolism and the WalK/WalR (YycG/YycF) Essential Two‑Component System
Sarah Dubrac and Tarek Msadek
In order to survive, bacteria have developed a variety of highly sophisticated and sensitive signal transduction pathways with which they adapt their genetic expression to meet the challenges of their...
