Chapter category:

The Role of Mammalian Coronins in Development and Disease

This chapter appears in the following book:

The Coronin Family of Proteins

Edited by: Christoph Clemen, Ludwig Eichinger and Vasily Rybakin
ISBN: 978-0-387-09594-3
» Get more information about this book at landesbioscience.com «

Chapter authors:
David W. Roadcap, Christoph S. Clemen and James E. Bear

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Coronins have maintained a high degree of conservation over the roughly 800 million years of eukaryotic evolution. From its origins as a single gene in simpler eukaryotes, the mammalian Coronin gene family has expanded to include at least six members (see chapter II‑2). Increasing evidence indicates that Coronins play critical roles as regulators of actin dependent processes such as cell motility and vesicle trafficking (see chapters III‑1 to 4). Considering the importance of these processes, it is not surprising that recent findings have implicated the involvement of Coronins in multiple diseases. This review primarily focuses on Coronin 1C (HGNC symbol: CORO1C, also known as Coronin 3) which is a transcriptionally dynamic gene that is up‑regulated in multiple types of clinically aggressive cancer. In addition to reviewing the molecular signals and events that lead to Coronin 1C transcription, we summarize the results of several studies describing the possible functional roles of Coronin 1C in development as well as disease progression. Here, the main focus is on brain development and on the progression of melanoma and glioma. Finally, we will also review the role of other mammalian Coronin genes in clinically relevant processes such as neural regeneration and pathogenic bacterial infections (see chapter IV‑1).

David W. Roadcap

Christoph S. Clemen

James E. Bear
UNC-Chapel Hill, Lineberger Comprehensive Cancer Center and Department of Cell and Developmental Biology

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Additional chapters from this book:

Role of Mammalian Coronin 7 in the Biosynthetic Pathway

Vasily Rybakin

Most coronin proteins rely on interaction with actin in their functions. Mammalian coronin 7 has not been shown to interact with actin, but rather to bind to the outer side of Golgi complex membranes....

Editorial:
The Coronin Family of Proteins

Christoph S. Clemen, Vasily Rybakin and Ludwig Eichinger

The coronins, first described in Dictyostelium discoideum in 1991, have meanwhile been detected in all eukaryotes except plants. They belong to the superfamily of WD40‑repeat proteins and repres...

Diversity of WD‑Repeat Proteins

Temple F. Smith

The WD‑repeat‑containing proteins form a very large family that is diverse in both its function and domain structure. Within all these proteins the WD‑repeat domains are thought to h...

A Brief History of the Coronin Family

Eugenio L. de Hostos

What I’d like to do in this chapter is to share with you my recollections from the earliest days of coronin research and then to provide an overview of the still‑developing story of this fascina...

Phylogenetic, Structural and Functional Relationships between WD‑ and Kelch‑Repeat Proteins

Andrew M. Hudson and Lynn Cooley

The β‑propeller domain is a widespread protein organizational motif. Typically, β‑propeller proteins are encoded by repeated sequences where each repeat unit corresponds to a twi...

The Role of Mammalian Coronins in Development and Disease

David W. Roadcap, Christoph S. Clemen and James E. Bear

Invertebrate Coronins

Maria Christina Shina and Angelika A. Noegel

Coronins are highly conserved among species, but their function is far from being understood in detail. Here we will introduce members of the family of coronin like proteins from Drosophila melanogast...

Evolutionary and Functional Diversity of Coronin Proteins

Charles-Peter Xavier, Ludwig Eichinger, M. Pilar Fernandez, Reginald O. Morgan and Christoph Clemen

This chapter discusses various aspects of coronin phylogeny, structure and function that are of specific interest. Two sub families of ancient coronins of unicellular pathogens such as Entamoeba, Tryp...

Coronin: The Double-Edged Sword of Actin Dynamics

Meghal Gandhi and Bruce L. Goode

Coronin is a conserved actin binding protein that promotes cellular processes that rely on rapid remodeling of the actin cytoskeleton, including endocytosis and cell motility. However, the exact mecha...

Coronin 1 in Innate Immunity

Jean Pieters

The WD repeat containing family of coronin proteins is generally referred to as F‑actin‑interacting proteins. While in lower eukaryotes such as Dictyostelium discoideum, the single short c...

Molecular Phylogeny and Evolution of the Coronin Gene Family

Reginald O. Morgan and M. Pilar Fernandez

The coronin gene family comprises seven vertebrate paralogs and at least five unclassified subfamilies in nonvertebrate metazoa, fungi and protozoa, but no representatives in plants or distant protist...

Coronin Structure and Implications

Bernadette McArdle and Andreas Hofmann

Until recently, structural information about coronins was scarce and the earlier identification of five WD40 repeats gave rise to a structural prediction of a five‑bladed β propeller for th...

Chapter category:

The Role of Mammalian Coronins in Development and Disease

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