Chapter category:
Neurotrophic Support of Midbrain Dopaminergic Neurons
Development and Engineering of Dopamine Neurons
Edited by: R. Jeroen Pasterkamp, Marten P. Smidt and J. Peter H. BurbachISBN: TBA
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Chapter authors:
Oliver von Bohlen
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Oliver von Bohlen
Interdisciplinary Center for Neurosciences, Neuroanatomy, University of Heidelberg
Additional chapters from this book:
Neurotrophic Support of Midbrain Dopaminergic Neurons
Oliver von Bohlen
In this chapter we review work on neurotrophic factors for midbrain dopaminergic neurons mainly from the past decade, with a focus on neurotrophins and fibroblast growth factors. We summarize data obt...
Dopamine Systems in the Forebrain
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The brain contains a number of distinct regions that share expression of dopamine (DA) and its requisite biosynthetic machinery, but otherwise encompass a diverse array of features and functions. Acro...
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Transforming growth factor betas (TGF‑βs) are multifunctional cytokines with widespread distribution. In the nervous system the biological effects of TGF‑β cover regulation of pr...
Development of the Dopamine Systems in Zebrafish
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Dopaminergic neurons develop in several distinct regions of the vertebrate brain and project locally or send long axonal projections to distant parts of the CNS to modulate the activity of a variety o...
Molecular and Cellular Determinants for Generating ES‑Cell Derived Dopamine Neurons for Cell Therapy
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Embryonic stem (ES) cells can generate midbrain dopaminergic (DA) neuronal phenotypes in vitro and have been successfully applied to restore function in animal models of Parkinson’s disease (PD). How ...
The Role of Otx genes in Progenitor Domains of Ventral Midbrain
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The mesencephalic dopaminergic (mesDA) neurons play a relevant role in the control of movement, behaviour and cognition. Indeed loss and/or abnormal development of mesDA neurons is responsible for Par...
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Meso‑diencephalic dopamine neurons (mdDA) neurons are located in the retrorubral field (RRF), substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) and give rise to prominent asc...
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The mammalian Engrailed genes were originally cloned by their sequence homology to the Drosophila engrailed. Orthologous genes of these homeobox transcription factors are found throughout the animal k...
Terminal Differentiation of Mesodiencephalic Dopaminergic Neurons: the role of Nurr1 and Pitx3
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The orphan nuclear hormone receptor Nurr1 and the homeobox Pitx3 were the first two transcription factors that were implicated in the development of mesodiencephalic dopaminergic (mdDA) neurons.1,2 Th...
Foxa1 and Foxa2 Transcription Factors Regulate Differentiation of Midbrain Dopaminergic Neurons
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Midbrain dopaminergic neurons (mDA), comprising the substantia nigra pars compacta (A8), the ventral tegmental area (A9) and the retrorubal field (A10) subgroups, are generated from floor plate progen...
Protocols for Generating ES Cell‑Derived Dopamine Neurons
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Stem cells are defined by their ability to self‑renew and to differentiate into specific specialized cell types. Pluripotent stem cells such as embryonic stem cells are capable of differentiatin...
