Chapter category:
Coronin 1 in Innate Immunity
The Coronin Family of Proteins
Edited by: Christoph Clemen, Ludwig Eichinger and Vasily RybakinISBN: 978-0-387-09594-3
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Chapter authors:
Jean Pieters
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Jean Pieters
NIH/NIMH
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Additional chapters from this book:
Role of Mammalian Coronin 7 in the Biosynthetic Pathway
Vasily Rybakin
Most coronin proteins rely on interaction with actin in their functions. Mammalian coronin 7 has not been shown to interact with actin, but rather to bind to the outer side of Golgi complex membranes....
Editorial:The Coronin Family of Proteins
Christoph S. Clemen, Vasily Rybakin and Ludwig Eichinger
The coronins, first described in Dictyostelium discoideum in 1991, have meanwhile been detected in all eukaryotes except plants. They belong to the superfamily of WD40‑repeat proteins and repres...
Diversity of WD‑Repeat Proteins
Temple F. Smith
The WD‑repeat‑containing proteins form a very large family that is diverse in both its function and domain structure. Within all these proteins the WD‑repeat domains are thought to h...
A Brief History of the Coronin Family
Eugenio L. de Hostos
What I’d like to do in this chapter is to share with you my recollections from the earliest days of coronin research and then to provide an overview of the still‑developing story of this fascina...
Phylogenetic, Structural and Functional Relationships between WD‑ and Kelch‑Repeat Proteins
Andrew M. Hudson and Lynn Cooley
The β‑propeller domain is a widespread protein organizational motif. Typically, β‑propeller proteins are encoded by repeated sequences where each repeat unit corresponds to a twi...
The Role of Mammalian Coronins in Development and Disease
David W. Roadcap, Christoph S. Clemen and James E. Bear
Coronins have maintained a high degree of conservation over the roughly 800 million years of eukaryotic evolution. From its origins as a single gene in simpler eukaryotes, the mammalian Coronin gene f...
Invertebrate Coronins
Maria Christina Shina and Angelika A. Noegel
Coronins are highly conserved among species, but their function is far from being understood in detail. Here we will introduce members of the family of coronin like proteins from Drosophila melanogast...
Evolutionary and Functional Diversity of Coronin Proteins
Charles-Peter Xavier, Ludwig Eichinger, M. Pilar Fernandez, Reginald O. Morgan and Christoph Clemen
This chapter discusses various aspects of coronin phylogeny, structure and function that are of specific interest. Two sub families of ancient coronins of unicellular pathogens such as Entamoeba, Tryp...
Coronin: The Double-Edged Sword of Actin Dynamics
Meghal Gandhi and Bruce L. Goode
Coronin is a conserved actin binding protein that promotes cellular processes that rely on rapid remodeling of the actin cytoskeleton, including endocytosis and cell motility. However, the exact mecha...
Coronin 1 in Innate Immunity
Jean Pieters
The WD repeat containing family of coronin proteins is generally referred to as F‑actin‑interacting proteins. While in lower eukaryotes such as Dictyostelium discoideum, the single short c...
Molecular Phylogeny and Evolution of the Coronin Gene Family
Reginald O. Morgan and M. Pilar Fernandez
The coronin gene family comprises seven vertebrate paralogs and at least five unclassified subfamilies in nonvertebrate metazoa, fungi and protozoa, but no representatives in plants or distant protist...
Coronin Structure and Implications
Bernadette McArdle and Andreas Hofmann
Until recently, structural information about coronins was scarce and the earlier identification of five WD40 repeats gave rise to a structural prediction of a five‑bladed β propeller for th...
