Chapter category:
Ataxia Telangiectasia and its Overlap with Nijmegen Breakage Syndrome and Ataxia‑Like Disorders
Molecular Mechanisms
of Ataxia Telangiectasia
Edited by: Shamim I. AhmadISBN: TBA
» Get more information about this book at landesbioscience.com «
Chapter authors:
Lindsay G. Ball and Wei Xiao
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Lindsay G. Ball
Wei Xiao
Department of Microbiology and Immunology, University of Saskatchewan
Additional chapters from this book:
Oncogenesis in Ataxia Telangectasia: Roles of ATM, p53, NF‑kB and DDE Recombination Pathogenesis
David H. Dreyfus
The mechanistic basis of ATM (Ataxia Telangectasis Mutated) protein interactions with DNA hairpin and related double stranded DNA breaks, generated through V(D)J recombination, has been the subject of...
Cell Signaling in Ataxia Telangiectasia
Tetsuo Nakajima
Ataxia-telangiectasia (AT) is a disease with pleiotropic defects that include hypersensitivity to ionizing radiation, immunodeficiency and increased cancer risk and Ataxia Telangiectasia Mutated (ATM)...
Protein‑Protein Interactions in Ataxia Telangiectasia
Steven M. Shell and Yue Zou
Ataxia telangiectasia (AT) is an early‑onset genetic disorder characterized by progressive neurondegeneration, chromosome instability and an extreme sensitivity to DNA damaging agents such as io...
Ataxia Telangiectasia and its Overlap with Nijmegen Breakage Syndrome and Ataxia‑Like Disorders
Lindsay G. Ball and Wei Xiao
Ataxia Telangiectasia (AT), Nijmegen Breakage Syndrome (NBS) and AT‑Like Disorder (ATLD) are three closely related human diseases. AT, NBS and ATLD share several prominent cellular phenotypes in...
DNA Damage and Repair in Ataxia Telangiectasia
Melissa M. Adams and Phillip Carpenter
Defects in the gene Ataxia Telangiectasia Mutated (ATM) are responsible for the development of Ataxia Telangiectasia (AT), an incurable cancer‑prone disease that is accompanied by a pleiotropic ...
Cell Cycle Defects and Apoptosis in Ataxia telangiectasia
Deborah Wilsker and Fred Bunz
ATM is a key regulator of both cell cycle checkpoints and apoptosis. Cells lacking ATM are defective in critical responses to damaged DNA and particularly to the double strand DNA breaks caused by ion...
Ataxia Telangiectasia: An Oxidative Stress‑Related Disease
Giovanni Pagano, Paolo Degan and Giuseppe Castello
Multi‑factorial information is available on Ataxia Telangiectasia (AT) phenotype associated with oxidative stress. First, the protein encoded by the AT gene (ATM) is involved in both the regulat...
Chromosomal Instability in Ataxia Telangiectasia
Luitpold V. Distel
Ataxia telangiectasia (AT) is a syndrome with multiple symptoms, of them one is the frequent and early onset of cancer. The disease is triggered by a mutation in the ATM‑gene. The gene and its e...
Mutations in the Ataxia Telangiectasia Mutated (ATM) Gene
Akira Tachibana
Ataxia telangiectasia (AT) is a multisystem autosomal recessive disorder by mutations in a single gene, ATM. A large number of mutations in this gene have been identified so far. In most cases of AT p...
