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Chapter category: Transplant

Science of Organ Preservation

This chapter appears in the following book:

Organ Preservation for Transplantation,
Third Edition

Edited by: Luis H. Toledo-Pereyra
ISBN: TBA
» Get more information about this book at landesbioscience.com «

Chapter authors:
Roberto Anaya-Prado, Luis H. Toledo-Pereyra and Juan M. Palma-Vargas


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The goal of organ preservation is to obtain perfect preservation for as long as needed. Unfortunately, this has not been accomplished for the majority of organs; although the use of different techniques and solutions for preservation has modified and improved the results observed both clinically and experimentally. Hypothermia has long been considered to be an essential component of organ preservation. Therefore, it has been used both alone and in combination with perfusion techniques in order to protect organs from ischemia/reperfusion injury. The use of various preservation solutions has modified and improved some of the results observed in experimental and clinical organ transplantation. In this chapter, we analyze recent advances in organ preservation both clinically and experimentally; it also explores the basic mechanisms involved during hypothermia and reperfusion organ preservation, with special attention to efforts being done in refining solutions and preservation techniques.

Roberto Anaya-Prado
Biomedical Diagnostics & Research, Inc.

Luis H. Toledo-Pereyra
Michigan State University
Kalamazoo Center for Medical Studies

Juan M. Palma-Vargas
Biomedical Diagnostics & Research, Inc.

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Additional chapters from this book:

Cellular and Molecular Biology in Organ Ischemia‑Reperfusion Injury

Shohachi Suzuki

Ischemia‑reperfusion injury (IRI) is a multifactorial disorder which leads to cellular damage and organ dysfunction. A vast number of studies on IRI have shown that this critical pathophysiologi...

Science of Organ Preservation

Roberto Anaya-Prado, Luis H. Toledo-Pereyra and Juan M. Palma-Vargas

The goal of organ preservation is to obtain perfect preservation for as long as needed. Unfortunately, this has not been accomplished for the majority of organs; although the use of different techniqu...

Perfusion and Storage Techniques

Amer Rajab, Ronald P Pelletier and Mitchell L Henry

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Pancreas Preservation

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Pancreas preservation is an essential process prior to both pancreas transplantation and islet isolation. Traditionally, research on pancreas preservation focused on pancreas transplantation. Recently...

Metabolic Management

Sufan Chien

The removal of an organ, which is subjected to an unnatural environment necessitates special management strategies that differ from in vivo management. The normal human body and the bodies of other ma...


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